ID G5AX92_HETGA Unreviewed; 822 AA.
AC G5AX92;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Pentatricopeptide repeat-containing protein 1 {ECO:0000313|EMBL:EHB01653.1};
GN ORFNames=GW7_06631 {ECO:0000313|EMBL:EHB01653.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB01653.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB01653.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- FUNCTION: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or
CC Complex V) produces ATP from ADP in the presence of a proton gradient
CC across the membrane which is generated by electron transport complexes
CC of the respiratory chain. F-type ATPases consist of two structural
CC domains, F(1) - containing the extramembraneous catalytic core and F(0)
CC - containing the membrane proton channel, linked together by a central
CC stalk and a peripheral stalk. During catalysis, ATP synthesis in the
CC catalytic domain of F(1) is coupled via a rotary mechanism of the
CC central stalk subunits to proton translocation. Part of the complex
CC F(0) domain. Minor subunit located with subunit a in the membrane.
CC {ECO:0000256|ARBA:ARBA00024864}.
CC -!- SIMILARITY: Belongs to the ATPase F chain family.
CC {ECO:0000256|ARBA:ARBA00005895}.
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DR EMBL; JH167378; EHB01653.1; -; Genomic_DNA.
DR AlphaFoldDB; G5AX92; -.
DR STRING; 10181.G5AX92; -.
DR InParanoid; G5AX92; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR InterPro; IPR019344; F1F0-ATPsyn_F_prd.
DR InterPro; IPR002885; Pentatricopeptide_rpt.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR NCBIfam; TIGR00756; PPR; 1.
DR PANTHER; PTHR24014; 2-OXOGLUTARATE AND IRON-DEPENDENT OXYGENASE DOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR24014:SF6; PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 1, MITOCHONDRIAL; 1.
DR Pfam; PF13041; PPR_2; 1.
DR Pfam; PF13812; PPR_3; 2.
DR Pfam; PF10206; WRW; 1.
DR PROSITE; PS51375; PPR; 2.
PE 3: Inferred from homology;
KW Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT REPEAT 250..284
FT /note="PPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00708"
FT REPEAT 359..395
FT /note="PPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00708"
FT REGION 153..179
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 432..452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 473..508
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 799..822
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 822 AA; 91668 MW; E396BEFF37D0AB36 CRC64;
MASVVPVKEK KLMDVKLGEL PSWILMRDFT PSGIVGAFQR GYYRYYNKYI NVKKGSIAGL
NMVLAAYVIF SYCFSYKELS AGGTGKPEMD LVRLSRLFCS PCPVGLSILQ HLNPLGARWA
GGREQLAMWQ TWQVSACSSF SCRLPLGQRS QKNLRSLPSD PSQPSPVAPQ EEEEEEGFGT
LSNKYSSRKL FHKSTAQLYN LRLGEQSDEE EELEPKLWRG RRNTPYWYFF QCKRLIKEGK
MLKEERLQPL ECNYTVLIGG CGRAGYLKKA FRLYNDMKKR DLEPSDATYT ALFNVCAESP
WKDSALQTAL KLQQQLRAKN FQLNLKTYHA LLKVAAKCAD LRMCLDVLKE IVHKGHVLTE
ETFNFLLMGC IQDKTTGFRY ALQVWRQMLS LGLEPNRHSY NLLLGAARDC GLGDPEVASR
LLLKPREEMV LIQSPTGKQR AGRRDRPRAD GGMSARLHTE ALERQLFMEL SPSLEAPPEP
SEATVPGKAQ PEMGTKAEPS HTAALAPGSL KSPPLELVEV NLLALGAVSP AVVSLGTVTT
PADRLVLMGG LEGFLGKMAE HGLQPDIKTL TLLAEMVEPG SPAESSLLSV LDRHKVEADV
TFFNTLMRKK SRLGDLEGAK VLLNPALPTL VSVDSGSGLG ALKAPGAKTE GRYGQLRSMW
WQALLPVLAK RGLIPNLQTF CNLAIGCHRP GDGLQLLADM KKSHMTPNVH IYSTLINAAL
KKLDYTYLIG ILRDMKQSRV PVNEVVIRQL EFAAKYPPTF DRYQGKNTYL EKIDGFRAYY
KQWLKAMPAE ETPHPWQVFQ TKPKGGQDTV RDTGVDRGLG GR
//
