ID G5AYR4_HETGA Unreviewed; 194 AA.
AC G5AYR4;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Histone H1.0 {ECO:0000256|ARBA:ARBA00040426};
DE AltName: Full=Histone H1(0) {ECO:0000256|ARBA:ARBA00043204};
GN Name=H1F0 {ECO:0000313|EMBL:JAO03128.1};
GN ORFNames=GW7_02561 {ECO:0000313|EMBL:EHB02184.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB02184.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB02184.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
RN [2] {ECO:0000313|EMBL:JAO03128.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Kidney {ECO:0000313|EMBL:JAO03128.1};
RA Bens M., Sahm A., Jahn N., Morhart M., Holtze S., Hildebrandt T.B.,
RA Platzer M., Szafranski K.;
RT "FRAMA: From RNA-seq data to annotated mRNA assemblies.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Histones H1 are necessary for the condensation of nucleosome
CC chains into higher-order structures. The histones H1.0 are found in
CC cells that are in terminal stages of differentiation or that have low
CC rates of cell division. {ECO:0000256|ARBA:ARBA00037763}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU003894}.
CC -!- SIMILARITY: Belongs to the histone H1/H5 family.
CC {ECO:0000256|RuleBase:RU003894}.
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DR EMBL; JH167581; EHB02184.1; -; Genomic_DNA.
DR EMBL; GEBF01000505; JAO03128.1; -; Transcribed_RNA.
DR AlphaFoldDB; G5AYR4; -.
DR STRING; 10181.G5AYR4; -.
DR eggNOG; KOG4012; Eukaryota.
DR InParanoid; G5AYR4; -.
DR OMA; KSTHASY; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0000786; C:nucleosome; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR GO; GO:0006334; P:nucleosome assembly; IEA:InterPro.
DR CDD; cd00073; H15; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR005819; H1/H5.
DR InterPro; IPR005818; Histone_H1/H5_H15.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11467; HISTONE H1; 1.
DR PANTHER; PTHR11467:SF154; HISTONE H1.0; 1.
DR Pfam; PF00538; Linker_histone; 1.
DR PRINTS; PR00624; HISTONEH5.
DR SMART; SM00526; H15; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51504; H15; 1.
PE 3: Inferred from homology;
KW Chromosome {ECO:0000256|RuleBase:RU003894};
KW Citrullination {ECO:0000256|ARBA:ARBA00022934};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003894};
KW Nucleus {ECO:0000256|RuleBase:RU003894};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813}.
FT DOMAIN 24..97
FT /note="H15"
FT /evidence="ECO:0000259|PROSITE:PS51504"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 98..194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 98..120
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 121..194
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 194 AA; 20873 MW; 1F8F6D83B73A79EC CRC64;
MTENSTSTPA AKPKRAKASK KSTDHPKYSD MIVAAIQTEK NRAGSSRQSI QKYIKSHYKV
GENADSQIKL SIKRLVTTGV LKQTKGVGAS GSFRLAKSDE PKRAVAFKKT KKEVKKVATP
KKAAKPKKAA SKAPSKKPKA TPVKKAKKKP AATPKKAKKP KVVKAKPVKA SKPKKAKPVK
PKAKSSAKRA GKKK
//
