ID G5AZ20_HETGA Unreviewed; 1004 AA.
AC G5AZ20;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Gamma-aminobutyric acid type B receptor subunit 2 {ECO:0000313|EMBL:EHB02290.1};
GN ORFNames=GW7_05037 {ECO:0000313|EMBL:EHB02290.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB02290.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB02290.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family. GABA-B
CC receptor subfamily. {ECO:0000256|ARBA:ARBA00008991}.
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DR EMBL; JH167586; EHB02290.1; -; Genomic_DNA.
DR AlphaFoldDB; G5AZ20; -.
DR STRING; 10181.G5AZ20; -.
DR eggNOG; KOG1055; Eukaryota.
DR InParanoid; G5AZ20; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004965; F:G protein-coupled GABA receptor activity; IEA:InterPro.
DR CDD; cd15294; 7tmC_GABA-B-R2; 1.
DR CDD; cd06366; PBP1_GABAb_receptor; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR041689; GBR2_CC.
DR InterPro; IPR002455; GPCR3_GABA-B.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR002457; GPCR_3_GABA_rcpt_B2.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR10519; GABA-B RECEPTOR; 1.
DR PANTHER; PTHR10519:SF20; GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 2; 1.
DR Pfam; PF00003; 7tm_3; 2.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF18455; GBR2_CC; 1.
DR PRINTS; PR01178; GABAB2RECPTR.
DR PRINTS; PR01176; GABABRECEPTR.
DR PRINTS; PR00248; GPCRMGR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:EHB02290.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 441..464
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 484..505
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 517..538
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 559..580
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 716..739
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 759..775
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 781..804
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 443..826
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT REGION 654..673
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 826..854
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 835..854
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1004 AA; 113420 MW; 29E108E2CBD9F0D6 CRC64;
MGLMPLTKEV AKGSIGRGVL PAVELAIEQI RNESLLRPYF LDLRLYDTEC DNAKGLKAFY
DAIKYGPNHL MVFGGVCPSV TSIIAESLQG WNLVQLSFAA TTPVLADKKK YPYFFRTVPS
DNAVNPAILK LLKHYHWRRV GTLTQDVQRF SEVRNDLTGV LYGEDIEISD TESFSNDPCT
SVKKLKGNDV RIILGQFDQN MAAKVFCCAY EENMFGSKYQ WIIPGWYEPS WWEQVRTKAN
SSRCLRKNLL AAMEGYIGVD FEPLSSKQIK TISGKTPQQY EREYNSKRSG VGPSKFHGYA
YDGIWVIAKT LQRTMETLHA SSRHQRIQDF NYTDHTLGRI ILSAMNETNF FGVTGQVVFR
NGERMGTIKF TQFQVIKAVN QAQQNSEEEK SIFEDSREVK VGEYNAVADT LEIINDTIRF
QGSEPPKDKT IILEQLRKIS LPLYSILSAL TILGMIMASA FLFFNIKNRN QKLIKMSSPY
MNNLIILGGM LSYASIFLFG LDGSFVSEKT FETLCTVRTW ILTVGYTTAF GAMFAKTWRV
HAIFKNVKMK KKIIKDQKLL VIVGGMLLID LCILICWQAV DPLRRTVERY SMEGCTQHPS
EQADVWLWLL SLTPWPLCHY QASSYGFSGP FHPQLWPPYH SSENPDNLAL SKMTSTKKSG
EGSGEWNKPG VDRDRSCRME MEGVLEPDSG RPPVPDPAGR DISIRPLLEH CENTHMTIWL
GIVYAYKGLL MLFGCFLAWE TRNVSIPALN DSKYIGMSVY NVGIMCIIGA AVSFLTRDQP
NVQFCIVALV IIFCSTITLC LVFVPKLITL RTNPDAATQN KRLQITRNQK KEDSKTSTSV
TSVNQASTSR LEGLQSENHR LRMKITELDK DLEEVTMQLQ DTPEKTTYIK QNHYQELNDI
LNLGNFTEST DGGKAILKNH LDQNPQLQWS TTEPSRTCKD PIEDINSPEH IQRRLSLQLP
ILHHAYLPSI GGVDASCVSP CVSPTASPRH RHVPPSFRVM VSGL
//
