ID G5AZ56_HETGA Unreviewed; 1707 AA.
AC G5AZ56;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=5'-3' exoribonuclease 1 {ECO:0000256|PIRNR:PIRNR006743};
DE EC=3.1.13.- {ECO:0000256|PIRNR:PIRNR006743};
GN ORFNames=GW7_20188 {ECO:0000313|EMBL:EHB02317.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB02317.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB02317.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR006743}.
CC -!- SIMILARITY: Belongs to the 5'-3' exonuclease family.
CC {ECO:0000256|PIRNR:PIRNR006743}.
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DR EMBL; JH167593; EHB02317.1; -; Genomic_DNA.
DR STRING; 10181.G5AZ56; -.
DR eggNOG; KOG2045; Eukaryota.
DR InParanoid; G5AZ56; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008409; F:5'-3' exonuclease activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000956; P:nuclear-transcribed mRNA catabolic process; IEA:InterPro.
DR CDD; cd18673; PIN_XRN1-2-like; 1.
DR Gene3D; 1.25.40.1050; -; 1.
DR Gene3D; 2.170.260.40; -; 1.
DR Gene3D; 2.30.30.750; -; 1.
DR Gene3D; 3.40.50.12390; -; 1.
DR InterPro; IPR027073; 5_3_exoribonuclease.
DR InterPro; IPR016494; 5_3_exoribonuclease_1.
DR InterPro; IPR041385; SH3_12.
DR InterPro; IPR040992; XRN1_D1.
DR InterPro; IPR047007; XRN1_D1_sf.
DR InterPro; IPR041106; XRN1_D2_D3.
DR InterPro; IPR041412; Xrn1_helical.
DR InterPro; IPR004859; Xrn1_N.
DR InterPro; IPR047008; XRN1_SH3_sf.
DR PANTHER; PTHR12341:SF41; 5'-3' EXORIBONUCLEASE 1; 1.
DR PANTHER; PTHR12341; 5'->3' EXORIBONUCLEASE; 1.
DR Pfam; PF18129; SH3_12; 1.
DR Pfam; PF18332; XRN1_D1; 1.
DR Pfam; PF18334; XRN1_D2_D3; 1.
DR Pfam; PF17846; XRN_M; 1.
DR Pfam; PF03159; XRN_N; 1.
DR PIRSF; PIRSF006743; Exonuclease_Xnr1; 2.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR006743};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000256|PIRNR:PIRNR006743};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PIRNR:PIRNR006743};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|PIRNR:PIRNR006743};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW RNA-binding {ECO:0000256|PIRNR:PIRNR006743}.
FT DOMAIN 1..227
FT /note="Xrn1 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF03159"
FT DOMAIN 272..597
FT /note="Xrn1 helical"
FT /evidence="ECO:0000259|Pfam:PF17846"
FT DOMAIN 654..844
FT /note="5'-3' exoribonuclease 1 D1"
FT /evidence="ECO:0000259|Pfam:PF18332"
FT DOMAIN 850..1075
FT /note="Exoribonuclease Xrn1 D2/D3"
FT /evidence="ECO:0000259|Pfam:PF18334"
FT DOMAIN 1102..1171
FT /note="5'-3' exoribonuclease 1 SH3-like"
FT /evidence="ECO:0000259|Pfam:PF18129"
FT REGION 1283..1317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1617..1707
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1283..1305
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1618..1694
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1707 AA; 193754 MW; 6BA0B96F6620F13D CRC64;
MGVPKFYRWI SERYPCLSEV VKEHQIPEFD NLYLDMNGII HQCSHPNDDD VHFRISDDKI
FTDIFHYLEV LFRIIKPRKV FFMAVDGVAP RAKMNQQRGR RFRSAKEAED KIKKAIEKGE
TLPTEARFDS NCITPGTEFM ARLHEHLKYF VNVKISTDKS WQGVTIYFSG HETPGEGEHK
IMEFIRSEKA KPDHDPNTRH CLYGLDADLI MLGLTSHEAH FSLLREEVRF GGKKTQRVCA
PEETTFHLLH LSLMREYIDY EFSVLKENIT FKYDIERIID DWILMGFLVG NDFIPHLPHL
HINHDALPLL YGTYITILPE LGGYINESGH LNLPRFEKYL VKLSDFDREH FSEVFVDLKW
FESKVGNKYL NEAAGIAAEE AKNYKEKKKS KGQENSVCWA ALDKSEGEMV VSKDNLEDET
EDDDLFETEF RQYKRTYYMT KMGVDVVSDD FLADQAVCYV QAIQWILHYY YHGVQSWSWY
YPYHYAPFLS DIRNISTLKI HFELGKPFKP FEQLLAVLPA ASKNLLPVCY QHLMTSEDSP
IIEYYPPDFK TDLNGKQQEW EAVVLIPFID EKRLLEAMET CNHSLKEEER KRNRHSECLM
CWYDKDTEFI YPSPWPEKFP AIERCYTRYK IISLDAWHVD ISKNKITRVD QKALYFCGFP
TLKHIKHKFF LKKSGVQVFQ QSSRGENMML EILVNAESDE LSIENVASSV LGKSVFVNWP
HLEEARVVAV SDGETKFYLE EPPGTQKLYL GRTAPPSKVI HLGDKEQSNW TKEVQGISEH
YLRRKGIIIN ETSMVVYAQL LTGRKYQINH NGEVRLEKQW SKQILPFVYQ TIVKDIQAFD
SRFSSIKTLD DLFPPGSVVF MLGTPYYGCT GEVQVSGDVI TEGRIRVVFS IPCEPNLDAL
IQNQHKYSIK YNPGYVLASR LGVSGYLVSR FTGSIFIGRG SRRNPHGDHK ANVGLNLKFN
KKNEEVPGYT KKVGSEWMYS SAAEQLLAEY LERAPELFSY IAKNSQEDVF YEDDIWPGEN
ENGAEKVQEI ITWLKGHPVS TLSRSSCDLQ ILDAAIVEKI EEEVDKCKQR KNNKKVRVTV
KPHLLYRPLE QQHGVIPDRD AEFRLFDRVV NVRENFSVPV GLRGTIIGIK GANREADVLF
EVLFDEEFPG GLTIRCSPGK GYRLPTSALV NLSHGSRSET GNQKLTAIVK PQPAVNQYSS
NSSVSPGHLG GLNHSSQSLF VPTQVSTKAD DEFCNIWQSL QGSRKIQHFQ PSIQEKGPVL
PQEISQVIQQ HKSGFYDNSV KYQQRKHEPH RKFKEECKSP KAECRSQKMS SKQPNSGIEN
FLASLNISKE NELPSSHHGE PPNEEHLSPQ SFAMGTRMLK EILKIDGSDT VDPKNEMKRY
GNEVTVSSNR RDEYGLSSQP KQNKKLAPYM NKLHRANEYH SIPSVDSTCW PIPSQVSSVS
TPVTELARIC SLVGMPQPDF SFLRTPQTMT VCQVKLSNGL LVHGPQCRSE NEAKEKAALF
ALQQLGSLGV NFPLPPPLFP NYPPAIPPGT IPPVFPQPPD HYGSNLALGP ANIMPSSPRL
FGSVPWGPPL PVPGKPFHQT LYPGAVPTAG GIMPGGAHNQ FIPLQVMKKR VANKKNFENK
ETQSSSQATP TQTSKPGSSD IAKVTAQESS SAPLNSSQVA QAASSFQGET ASHGSHNAPH
QKAAPSSSSR RRSRKLAVNF GVSKPSE
//
