ID G5AZ70_HETGA Unreviewed; 594 AA.
AC G5AZ70;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Solute carrier family 23 member 1 {ECO:0000313|EMBL:EHB02331.1};
DE Flags: Fragment;
GN ORFNames=GW7_21305 {ECO:0000313|EMBL:EHB02331.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB02331.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB02331.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC 2.A.40) family. {ECO:0000256|ARBA:ARBA00008821}.
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DR EMBL; JH167594; EHB02331.1; -; Genomic_DNA.
DR AlphaFoldDB; G5AZ70; -.
DR STRING; 10181.G5AZ70; -.
DR eggNOG; KOG1292; Eukaryota.
DR InParanoid; G5AZ70; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0071702; P:organic substance transport; IEA:UniProt.
DR InterPro; IPR006043; NCS2.
DR PANTHER; PTHR11119:SF21; SOLUTE CARRIER FAMILY 23 MEMBER 1; 1.
DR PANTHER; PTHR11119; XANTHINE-URACIL / VITAMIN C PERMEASE FAMILY MEMBER; 1.
DR Pfam; PF00860; Xan_ur_permease; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 36..62
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 74..96
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 155..179
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 214..234
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 246..268
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 307..329
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 395..417
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 423..442
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 454..471
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 487..507
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 574..594
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 594
FT /evidence="ECO:0000313|EMBL:EHB02331.1"
SQ SEQUENCE 594 AA; 64164 MW; 95B21ECFDEB14052 CRC64;
QQDPQGSKGA STRNPKMSLP TEPKTDMLYK IEDVPPWYLC ILLGFQHYLT CFSGTIAVPF
LLAEALCVGH DQYMVSQLIG TIFTCVGITT LIQTTLGIRL PLFQASAFAF LVPAKAILAL
EKWKCPPEEE IYGNWSLPLN TSHIWHPRMR EIQGAIMVSS IVEVVIGLTG LPGALLSYIG
PLTVTPTVSL IGLSVFQAAG DRAGSHWGIS SCSILLIVLF SQYLRNVAFL LPVYRWSKGL
TLFRIQIFKM FPIVLAIMTV WLLCYVLTLT DVLPSDPTAY GFQARTDARG DIMAISPWIR
IPYPCQWGLP TVTVAAVLGM FSATLAGIIE SIGDYYACAR LAGAPPPPVH AINRGIFTEG
ICCIIAGLLG TGNGSTSSSP NIGVLGITKV GSRRVVQYGA GIMLVLGAVG KFTALFASLP
DPILGGMFCT LFGMITAVGL SNLQFVDMNS SRNLFVLGFP MFFGLTLPNY LDSNPGVINT
GIPEVDQILT VLLTTEMFVG GCLAFILDNT VPGSPEERGL IQWKAGAHAN SETSASLKSY
DFPIGMDTVK KIAFLKYIPI CPVFKGFSLR SKNHPPVQED TPENTEAVSV CTKV
//
