ID   G5AZA4_HETGA            Unreviewed;       441 AA.
AC   G5AZA4;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   27-MAR-2024, entry version 44.
DE   RecName: Full=Syndecan {ECO:0000256|RuleBase:RU000649};
GN   ORFNames=GW7_11037 {ECO:0000313|EMBL:EHB02369.1};
OS   Heterocephalus glaber (Naked mole rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC   Heterocephalus.
OX   NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB02369.1, ECO:0000313|Proteomes:UP000006813};
RN   [1] {ECO:0000313|EMBL:EHB02369.1, ECO:0000313|Proteomes:UP000006813}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993625; DOI=10.1038/nature10533;
RA   Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA   Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA   Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA   Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA   Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA   Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT   "Genome sequencing reveals insights into physiology and longevity of the
RT   naked mole rat.";
RL   Nature 479:223-227(2011).
CC   -!- FUNCTION: Cell surface proteoglycan. {ECO:0000256|RuleBase:RU000649}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC       ECO:0000256|RuleBase:RU000649}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU000649}.
CC       Secreted, extracellular exosome {ECO:0000256|ARBA:ARBA00004550}.
CC   -!- SIMILARITY: Belongs to the syndecan proteoglycan family.
CC       {ECO:0000256|ARBA:ARBA00005343, ECO:0000256|RuleBase:RU000649}.
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DR   EMBL; JH167601; EHB02369.1; -; Genomic_DNA.
DR   AlphaFoldDB; G5AZA4; -.
DR   STRING; 10181.G5AZA4; -.
DR   eggNOG; ENOG502RZWT; Eukaryota.
DR   InParanoid; G5AZA4; -.
DR   OMA; STWKDMA; -.
DR   Proteomes; UP000006813; Unassembled WGS sequence.
DR   Bgee; ENSHGLG00000018171; Expressed in liver and 9 other cell types or tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR003585; Neurexin-like.
DR   InterPro; IPR001050; Syndecan.
DR   InterPro; IPR027789; Syndecan/Neurexin_dom.
DR   InterPro; IPR030479; Syndecan_CS.
DR   PANTHER; PTHR10915; SYNDECAN; 1.
DR   PANTHER; PTHR10915:SF5; SYNDECAN-1; 1.
DR   Pfam; PF01034; Syndecan; 1.
DR   SMART; SM00294; 4.1m; 1.
DR   PROSITE; PS00964; SYNDECAN; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180,
KW   ECO:0000256|RuleBase:RU000649};
KW   Heparan sulfate {ECO:0000256|ARBA:ARBA00023207,
KW   ECO:0000256|RuleBase:RU000649};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Proteoglycan {ECO:0000256|ARBA:ARBA00022974,
KW   ECO:0000256|RuleBase:RU000649};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000649};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        383..407
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          406..424
FT                   /note="Neurexin/syndecan/glycophorin C"
FT                   /evidence="ECO:0000259|SMART:SM00294"
FT   REGION          171..193
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          216..349
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          414..441
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   441 AA;  44737 MW;  55D1133CB6296930 CRC64;
     MALGRPVVVS ARVLAASREQ RQGGGAGRGP GGLDSPRAIV SSSAGLCLGK WGAAAEESET
     SLCTQATREA VPCGQAQGGP LAHLRGGLLP RRQQRSCHAD VLMEPICSCA GLQPLGPRPC
     LAQLEAASPG PKADSRQRAA VPVAARVPPP LRGQALAHAC SHPLQQVVAT NLPPEDQDGS
     GDDSDTFSGS GAGALQDIAA SPQAPATGKD TWLLSVMPTV PEPGGREATA SSTPVLPAGE
     RQEEGEAAVP MGARPDLTAR EEGGEPKPRE PTQLPGTQRA QAPTSPHAPR DVHPGLAEGT
     APAASGQPDG LAPSAEGAGP SATESTEDGA PSQLPAGEGS GEQDFTFDSS GENVAVAAVD
     LDDRSEPPVG QGASQGLLGR KEVLGGVIAG GVVGLVFAVC LVGFMLYRMK KKDEGSYSLE
     EPKQANGGAY QKPTKQEEFY A
//