ID G5B249_HETGA Unreviewed; 430 AA.
AC G5B249;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=FAM69 protein-kinase domain-containing protein {ECO:0000259|Pfam:PF12260};
GN ORFNames=GW7_10973 {ECO:0000313|EMBL:EHB03360.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB03360.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB03360.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the DIPK family.
CC {ECO:0000256|ARBA:ARBA00006338}.
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DR EMBL; JH168064; EHB03360.1; -; Genomic_DNA.
DR RefSeq; XP_004834452.1; XM_004834395.1.
DR AlphaFoldDB; G5B249; -.
DR STRING; 10181.G5B249; -.
DR Ensembl; ENSHGLT00000071066; ENSHGLP00000032070; ENSHGLG00000049789.
DR Ensembl; ENSHGLT00100051891; ENSHGLP00100042690; ENSHGLG00100048261.
DR GeneID; 101707609; -.
DR KEGG; hgl:101707609; -.
DR CTD; 205428; -.
DR eggNOG; ENOG502QUEB; Eukaryota.
DR InParanoid; G5B249; -.
DR OMA; DICNHHL; -.
DR OrthoDB; 2919302at2759; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR Bgee; ENSHGLG00000018992; Expressed in testis and 10 other cell types or tissues.
DR GO; GO:0030137; C:COPI-coated vesicle; IEA:Ensembl.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0034392; P:negative regulation of smooth muscle cell apoptotic process; IEA:Ensembl.
DR InterPro; IPR020519; DIPK2A/B.
DR InterPro; IPR022049; FAM69_kinase_dom.
DR PANTHER; PTHR32073:SF6; DIVERGENT PROTEIN KINASE DOMAIN 2A; 1.
DR PANTHER; PTHR32073; GH11358P; 1.
DR Pfam; PF12260; PIP49_C; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 207..405
FT /note="FAM69 protein-kinase"
FT /evidence="ECO:0000259|Pfam:PF12260"
SQ SEQUENCE 430 AA; 49483 MW; 8D13482DF007BBC3 CRC64;
MWRLVPPKLG RLSRSLKLAA LGSLLVLMVL HSPSLLASWQ RNELTDRRFL QLNKCPACFG
TSWCRRFLNG QVVFEAWGRL RLLDFLNVKN VYFAQYGEPR EGGRRRVVLK RLGSQRELAQ
LDQSICKRAT GRPRCDLLQA MPRTEFARLN GDVRLLTPEA VEGWSDLVHC PSQRLLDRLV
RRYAETKDSG SFLLRNLKDS ERMQLLLTLA FNPEPLVLQS FPSDEGWPFA KYLGACGRMV
AVNYVGEELW SYFSAPWEKR VDLAWQLMEI AEQLTNNDFE FALYLLDVSF DNFAVGPRDG
KVIIVDAENV LVADKRLIRQ NKPENWDVWY ESKFDDCDKE ACLSFSKEIL CARVTVDHNY
YAVCQNLLSR HATWRGTSGG LLHDPPSEIA KDGRLEALLD ECANPKKRYG RFQAAKELRE
YLAQLSNNVR
//
