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Database: UniProt
Entry: G5B280_HETGA
LinkDB: G5B280_HETGA
Original site: G5B280_HETGA 
ID   G5B280_HETGA            Unreviewed;       811 AA.
AC   G5B280;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   10-OCT-2018, entry version 31.
DE   SubName: Full=Protein-glutamine gamma-glutamyltransferase K {ECO:0000313|EMBL:EHB03390.1};
GN   Name=TGM1 {ECO:0000313|EMBL:JAN97417.1};
GN   ORFNames=GW7_11952 {ECO:0000313|EMBL:EHB03390.1};
OS   Heterocephalus glaber (Naked mole rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricomorpha; Bathyergidae; Heterocephalus.
OX   NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB03390.1, ECO:0000313|Proteomes:UP000006813};
RN   [1] {ECO:0000313|EMBL:EHB03390.1, ECO:0000313|Proteomes:UP000006813}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993625; DOI=10.1038/nature10533;
RA   Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA   Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA   Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA   Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L.,
RA   Bronson R.T., Buffenstein R., Wang B., Han C., Li Q., Chen L.,
RA   Zhao W., Sunyaev S.R., Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT   "Genome sequencing reveals insights into physiology and longevity of
RT   the naked mole rat.";
RL   Nature 479:223-227(2011).
RN   [2] {ECO:0000313|EMBL:JAN97417.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Skin {ECO:0000313|EMBL:JAN97417.1};
RA   Bens M., Sahm A., Jahn N., Morhart M., Holtze S., Hildebrandt T.B.,
RA   Platzer M., Szafranski K.;
RT   "FRAMA: From RNA-seq data to annotated mRNA assemblies.";
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC         Evidence={ECO:0000256|PIRSR:PIRSR000459-2};
CC       Note=Binds 1 Ca(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR000459-2};
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DR   EMBL; JH168072; EHB03390.1; -; Genomic_DNA.
DR   EMBL; GEBF01006215; JAN97417.1; -; Transcribed_RNA.
DR   InParanoid; G5B280; -.
DR   Proteomes; UP000006813; Unassembled WGS sequence.
DR   GO; GO:0031224; C:intrinsic component of membrane; IEA:Ensembl.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003810; F:protein-glutamine gamma-glutamyltransferase activity; IEA:Ensembl.
DR   GO; GO:0030216; P:keratinocyte differentiation; IEA:Ensembl.
DR   GO; GO:0018149; P:peptide cross-linking; IEA:Ensembl.
DR   GO; GO:0045787; P:positive regulation of cell cycle; IEA:Ensembl.
DR   GO; GO:0010838; P:positive regulation of keratinocyte proliferation; IEA:Ensembl.
DR   Gene3D; 2.60.40.10; -; 3.
DR   Gene3D; 3.90.260.10; -; 1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR038765; Papain_like_cys_pep_sf.
DR   InterPro; IPR002931; Transglutaminase-like.
DR   InterPro; IPR036985; Transglutaminase-like_sf.
DR   InterPro; IPR023608; Transglutaminase_animal.
DR   InterPro; IPR013808; Transglutaminase_AS.
DR   InterPro; IPR008958; Transglutaminase_C.
DR   InterPro; IPR036238; Transglutaminase_C_sf.
DR   InterPro; IPR001102; Transglutaminase_N.
DR   Pfam; PF00927; Transglut_C; 2.
DR   Pfam; PF01841; Transglut_core; 1.
DR   Pfam; PF00868; Transglut_N; 1.
DR   PIRSF; PIRSF000459; TGM_EBP42; 1.
DR   SMART; SM00460; TGc; 1.
DR   SUPFAM; SSF49309; SSF49309; 2.
DR   SUPFAM; SSF54001; SSF54001; 1.
DR   SUPFAM; SSF81296; SSF81296; 1.
DR   PROSITE; PS00547; TRANSGLUTAMINASES; 1.
PE   4: Predicted;
KW   Calcium {ECO:0000256|PIRSR:PIRSR000459-2};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006813};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR000459-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW   Transferase {ECO:0000313|EMBL:EHB03390.1}.
FT   DOMAIN      364    457       TGc. {ECO:0000259|SMART:SM00460}.
FT   ACT_SITE    372    372       {ECO:0000256|PIRSR:PIRSR000459-1}.
FT   ACT_SITE    431    431       {ECO:0000256|PIRSR:PIRSR000459-1}.
FT   ACT_SITE    454    454       {ECO:0000256|PIRSR:PIRSR000459-1}.
FT   METAL       494    494       Calcium. {ECO:0000256|PIRSR:PIRSR000459-
FT                                2}.
FT   METAL       496    496       Calcium. {ECO:0000256|PIRSR:PIRSR000459-
FT                                2}.
FT   METAL       543    543       Calcium. {ECO:0000256|PIRSR:PIRSR000459-
FT                                2}.
FT   METAL       548    548       Calcium. {ECO:0000256|PIRSR:PIRSR000459-
FT                                2}.
SQ   SEQUENCE   811 AA;  89773 MW;  72CE6A2285BECA6B CRC64;
     MMDSSRSDMG RWGGNPLQPP ATPSPEPDRV WDRNRDRDRR RGGGARSFWA RCCGCCSCRN
     REDDDWGPEP SGSRNRGSSS WNRRPESRGS GVNAAGDGTV REGMLVVTRV DLLGSRSDQN
     RRDHHTDEFE YDELIVRRGQ PFYLVLFLNR PYESSDRMAL ELLIGNNPEV GKGTHVIIPV
     DKGSSGGWKA HVTKASGQNL NLRVHTSPSA IIGKFQFTVR TRCEAGEFQL PLDPRNEIYI
     LFNPWCPEDI VYVDHEDWRQ EYVLNESGRI YYGTEAQIGE RTWNYGQFDH GVLDACLYIL
     DRRGMPYGGR GDPVSVSRVI SAMVNSLDDN GVLIGNWSGD YSRGTNPSAW VGSVEILLSY
     LRTGYSVPYG QCWVFAGVTT TVLRCLGLAT RTVTNFNSAH DTDTSLTMDI YFDENMKPLE
     HLNHDSVWNF HVWNDCWMKR PDLPSGFDGW QVVDATPQET SSGIFCCGPC SVESIKNGLV
     YMKYDTPFIF AEVNSDKVYW QRQEDGSFKI VYVEEKAIGT LIVTKAISSN MREDITHTYK
     HPEGSEAERK AVETAAAHGS KPNVYASRDS TEDVAMQVEA QDAVMGQDLT VSVVLTNRGS
     NHRTVKLHLY LSVTYYTGVT GSIFKESKKE VALAPGASDR MTMPVAYKEY QPHLVDQGAM
     LLNVSGHVKE SGQVLAKQHT FRVRTPDLSL TLLGAAVVGQ ECEVQIIFKN PLPITLTKVV
     FRLEGSGLQR PKVLNVGDIG GNETVTLRQT FVPVRPGPRQ LIASLDSPQL SQVHGVIQVD
     VAPASGGGAF SEAGGDSRSG ESIPMASRGG A
//
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