ID G5B2I5_HETGA Unreviewed; 597 AA.
AC G5B2I5;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Pannexin {ECO:0000256|RuleBase:RU010713};
DE Flags: Fragment;
GN Name=PANX {ECO:0000256|RuleBase:RU010713};
GN ORFNames=GW7_00594 {ECO:0000313|EMBL:EHB03493.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB03493.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB03493.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- FUNCTION: Structural component of the gap junctions and the
CC hemichannels. {ECO:0000256|RuleBase:RU010713}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU010713};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU010713}. Cell
CC junction, gap junction {ECO:0000256|RuleBase:RU010713}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the pannexin family. {ECO:0000256|PROSITE-
CC ProRule:PRU00351, ECO:0000256|RuleBase:RU010713}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00351,
CC ECO:0000256|RuleBase:RU010713}.
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DR EMBL; JH168132; EHB03493.1; -; Genomic_DNA.
DR AlphaFoldDB; G5B2I5; -.
DR STRING; 10181.G5B2I5; -.
DR GlyCosmos; G5B2I5; 1 site, No reported glycans.
DR eggNOG; ENOG502QT63; Eukaryota.
DR InParanoid; G5B2I5; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0005921; C:gap junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015267; F:channel activity; IEA:InterPro.
DR GO; GO:0006812; P:monoatomic cation transport; IEA:InterPro.
DR GO; GO:0034220; P:monoatomic ion transmembrane transport; IEA:UniProtKB-KW.
DR GO; GO:0032732; P:positive regulation of interleukin-1 production; IEA:InterPro.
DR InterPro; IPR000990; Innexin.
DR InterPro; IPR039099; Pannexin.
DR PANTHER; PTHR15759; PANNEXIN; 1.
DR PANTHER; PTHR15759:SF7; PANNEXIN-2; 1.
DR Pfam; PF00876; Innexin; 1.
DR PROSITE; PS51013; PANNEXIN; 1.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|RuleBase:RU010713};
KW Gap junction {ECO:0000256|ARBA:ARBA00022868, ECO:0000256|PROSITE-
KW ProRule:PRU00351}; Glycoprotein {ECO:0000256|PIRSR:PIRSR600990-52};
KW Ion channel {ECO:0000256|RuleBase:RU010713};
KW Ion transport {ECO:0000256|RuleBase:RU010713};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00351}; Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00351};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|PROSITE-
KW ProRule:PRU00351}; Transport {ECO:0000256|RuleBase:RU010713}.
FT TRANSMEM 48..70
FT /note="Helical"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00351,
FT ECO:0000256|RuleBase:RU010713"
FT TRANSMEM 152..175
FT /note="Helical"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00351,
FT ECO:0000256|RuleBase:RU010713"
FT TRANSMEM 214..240
FT /note="Helical"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00351,
FT ECO:0000256|RuleBase:RU010713"
FT REGION 318..350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 318..336
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 11
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000256|PIRSR:PIRSR600990-52"
FT NON_TER 597
FT /evidence="ECO:0000313|EMBL:EHB03493.1"
SQ SEQUENCE 597 AA; 66165 MW; 737697E363146BC0 CRC64;
EEPIYCYTPH NFTRDQALYA RGYCWTELRD ALPGVDASLW PSLFEHKFLP YALLAFAAIM
YVPALGWEFL ASTRLTSELN FLLQEIDNCY HRAAEGRAPK IEKQIQSKGP GITEREKREI
IENAEKEKSP EQNLFEKYLE RRGRSNFLAK LYLARHVLIL LLSVVPISYL CTYYATQKQN
EFTCALGASP DGPAGGGPAV HVSCKLPSVQ LQRIIAGVDI VLLCFMNLII LVNLIHLFIF
RKSNFIFDKL HKVGIKTRRQ WRRSQFCDIN ILAMFCNENR DHIKSLNRLD FITNESDLMY
DNVVRQLLAA LAQSNHDATP TVRDSGIQTV DPSANPAEPD GSTEPPVVKR PRKKMKWIPT
SNPLPQPFKE QLAIMRVENS KAEKPKPVRR KTATDTLIAP LLDAGARAAH HYKGSGGDTG
TATAPDKKHA RHFSLDVHPY ILGARKAKPE TVPTALPASR SQEGGFLSQA EECGLGLATA
PTKDAPLPEK EAPYPTEPAR PGLPAGGPFH VCSPPAPPTV APLSPASLGK ADPLAILSRN
ATHPLLHINT LYEAREEEEG APRVPPDMGD LITIPPAQQI LIATFEEPRT VVSTVEF
//
