ID G5B301_HETGA Unreviewed; 1575 AA.
AC G5B301;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE SubName: Full=VPS10 domain-containing receptor SorCS2 {ECO:0000313|EMBL:EHB03676.1};
GN ORFNames=GW7_14565 {ECO:0000313|EMBL:EHB03676.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB03676.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB03676.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family. SORCS
CC subfamily. {ECO:0000256|ARBA:ARBA00010818}.
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DR EMBL; JH168156; EHB03676.1; -; Genomic_DNA.
DR STRING; 10181.G5B301; -.
DR eggNOG; KOG3511; Eukaryota.
DR InParanoid; G5B301; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.10.70.80; -; 1.
DR Gene3D; 3.30.60.270; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR022409; PKD/Chitinase_dom.
DR InterPro; IPR000601; PKD_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR PANTHER; PTHR12106:SF9; VPS10 DOMAIN-CONTAINING RECEPTOR SORCS2; 1.
DR Pfam; PF18911; PKD_4; 1.
DR Pfam; PF15902; Sortilin-Vps10; 2.
DR Pfam; PF15901; Sortilin_C; 1.
DR SMART; SM00089; PKD; 1.
DR SMART; SM00602; VPS10; 1.
DR SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 1.
DR SUPFAM; SSF49299; PKD domain; 1.
DR PROSITE; PS50093; PKD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000313|EMBL:EHB03676.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1178..1238
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT REGION 59..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 537..637
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 859..907
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1446..1470
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 538..552
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 570..604
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 609..625
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1575 AA; 172372 MW; DE6913A4C43D0CA5 CRC64;
MPHESHLLPP PEKAGNECLS RFAAGEKAVA GWEGGSKRVY KGSAIFCLAM ALTRAAVVTP
KGRQDPKDPP ASPHGKRKDS SHFHFRLVLG PQVERAPLSV WRLRQVILIL TKYYHADMGK
VLESSLWRSK APWLFSPTWL SFPVGLELRR GDGAVPATCP CHCPAIQGPD SALPGYELGL
DPLPDQMKFP QLAQKSQLSQ GGFSLSPSVV SSTEVAFCLQ PAELSRLALF FPAAGVAGAW
ACGVEAALQE RGPWSQAEPF GAICEEFRAS SSDFGTSYTK LTLQPGVTTI IDNFYICPTN
KRKIILVSSS LSDREQNLFL STDEGTSFQR QPITFLVETL LFHPRDEDKV LAYTKESKLY
VSLDLGKKWT LLQEQVTKDH VFWAVSGVDA DPNLVHMETQ DLSGGFRYVT CQIHSCSDEM
LAAPFPGPID HGSLAVQDDY VLLKTTSTNQ TKYYVSYRRN EFVLMKLPKY ALPKDLQVIS
TDESQVFVAG GEWYQTDTYN LYQSDPRGVR YALVLEDVRS SRQAEESVLI DILEGQTRRP
RPSSTVLTRC GTSGHGQVGV RECFPEEAAE LSSSQASSRD STGTDPGRGR SNSRGCTRSP
GSSGQDPDGD ARGKADTEEA EGPGGLERYS HGLDLQGPGS WDKHLRLEAP VCESHKGDLD
LSGESIGAQW ALGGPGAWKE AAEGIREVRG VKGVFLANRK VDGKVMTLIT YNKGRDWDFL
RPPSSDMNGK PTNCQPPDCH LHLHLRWADN PYVSGTVHTK DTTPGLIMGA GNLGSQLVEY
KEEMYITADC GRTWRQVFEE EHHILYLDHG GVIVAIKDTS IPLKILKFSV DGGVTWSTHN
FTSTSVFVDG LLSEPGDETL GTGWAAGAGP PGPHRASRGH WEPAGARQAP QPSTVQELGH
PGPAGSIVGP AAPELARLVF GHISFRSDWE LVKVDFRPSF SRPCGENDYS SWDLTSLQGD
RCIMGQQRSF RKRKPASWCV QGRSFTSALT ARVCQCRDSD FLCDYGFERT PSLEPGTKCV
ANFWFNPLAP PDDCAVGQTY TSSLGYRKVV SNVCEGGVDL WRGPGPLQCP LTRPRGLRVS
ILGEAVAVRP GEDVLFVVRQ EQVSGRGDRL GMGYRKVVSN VCEGGVDLWR GPGPLQCPLT
RPRGLRVSIL GEAVAVRPGE DVLFVVRQEQ GDILTTKYQV DLGDGFKAMY VNLTLTAEPI
RHRYESPGVY RVSVRAENVA GHDEAVLFVQ VNSPLQALYL EVAPVVGINQ DMNLTAVLLP
PNPNLTVFYW WIGHSLQPLL SLDNSVTTRF AAPGDVRVSV QAACGSSVLQ DSRVVRVLDQ
FQLVPLCFSR ELDALNPNTP EWREDVGLVV TRLLSKETSV PEELLVTVVR PGLPTVADLY
VLLPPPRPTR KRSLSSDKRL TAVRQVLSAQ KISFLLQGGL RVLVALRDTD TGARVAVLKL
PAAGGRGAAA WPGDQGRVQD GGLPGREAQT RVPCARRKRP GRTVYAQMHN EKEQEMTEVP
GSLSSSCRLQ EVEEQQRGQG IRVGTVYAQM HNEKEQEMTS PVSRSEDAQG TAMQGNHSGV
VLSINSREMH GYLVS
//
