ID G5B3H3_HETGA Unreviewed; 215 AA.
AC G5B3H3;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=Tumor necrosis factor ligand superfamily member 8 {ECO:0000313|EMBL:EHB03833.1};
GN ORFNames=GW7_01798 {ECO:0000313|EMBL:EHB03833.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB03833.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB03833.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SIMILARITY: Belongs to the tumor necrosis factor family.
CC {ECO:0000256|ARBA:ARBA00008670}.
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DR EMBL; JH168254; EHB03833.1; -; Genomic_DNA.
DR AlphaFoldDB; G5B3H3; -.
DR STRING; 10181.G5B3H3; -.
DR eggNOG; ENOG502S54A; Eukaryota.
DR InParanoid; G5B3H3; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR021184; TNF_CS.
DR InterPro; IPR006052; TNF_dom.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR32163; TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 8; 1.
DR PANTHER; PTHR32163:SF1; TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 8; 1.
DR Pfam; PF00229; TNF; 1.
DR SMART; SM00207; TNF; 1.
DR SUPFAM; SSF49842; TNF-like; 1.
DR PROSITE; PS00251; TNF_1; 1.
DR PROSITE; PS50049; TNF_2; 1.
PE 3: Inferred from homology;
KW Cytokine {ECO:0000256|ARBA:ARBA00022514};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..43
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 81..211
FT /note="TNF family profile"
FT /evidence="ECO:0000259|PROSITE:PS50049"
SQ SEQUENCE 215 AA; 24063 MW; F01881929C7B9582 CRC64;
MHVPPGSVAS HLGGTSRRCF YFTIATLALC LVFTVATIMV LVVQRTDSIL SPPGNSPHKG
ENCSDDLLCI LERAPFKKSR AYLKVSKHLN STKVSWNQDG ILNGVRYQDG NLVIQFPGLY
LIICQLQFRV QCSSHSVDLK LELLVNTKVK REALVTVCES GIQTKHIYQN LSQFLLDYLQ
ANTTISVTVN KFQYVDIDTF PRDNVLSVFL YSSSD
//
