ID   G5B444_HETGA            Unreviewed;       343 AA.
AC   G5B444;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   SubName: Full=Putative C->U-editing enzyme APOBEC-4 {ECO:0000313|EMBL:EHB04055.1};
GN   ORFNames=GW7_02149 {ECO:0000313|EMBL:EHB04055.1};
OS   Heterocephalus glaber (Naked mole rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC   Heterocephalus.
OX   NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB04055.1, ECO:0000313|Proteomes:UP000006813};
RN   [1] {ECO:0000313|EMBL:EHB04055.1, ECO:0000313|Proteomes:UP000006813}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993625; DOI=10.1038/nature10533;
RA   Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA   Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA   Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA   Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA   Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA   Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT   "Genome sequencing reveals insights into physiology and longevity of the
RT   naked mole rat.";
RL   Nature 479:223-227(2011).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
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DR   EMBL; JH168392; EHB04055.1; -; Genomic_DNA.
DR   AlphaFoldDB; G5B444; -.
DR   STRING; 10181.G5B444; -.
DR   eggNOG; ENOG502QQXT; Eukaryota.
DR   InParanoid; G5B444; -.
DR   Proteomes; UP000006813; Unassembled WGS sequence.
DR   Gene3D; 3.40.140.10; Cytidine Deaminase, domain 2; 1.
DR   InterPro; IPR038953; APOBEC4.
DR   InterPro; IPR002125; CMP_dCMP_dom.
DR   PANTHER; PTHR35672; C-U-EDITING ENZYME APOBEC-4-RELATED; 1.
DR   PANTHER; PTHR35672:SF1; C-U-EDITING ENZYME APOBEC-4-RELATED; 1.
DR   Pfam; PF18778; NAD1; 1.
DR   PROSITE; PS51747; CYT_DCMP_DEAMINASES_2; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000006813}.
FT   DOMAIN          64..180
FT                   /note="CMP/dCMP-type deaminase"
FT                   /evidence="ECO:0000259|PROSITE:PS51747"
SQ   SEQUENCE   343 AA;  38863 MW;  60D6A8C252D2B39C CRC64;
     MEPLYEEYLT HGGTIVKPYH WLNFSLDCTN CPYHIRTGEE ARVPHTEFHQ QNFVFGFPHG
     PTYPPTKHLT FYELKTSSGT LVQKGHASNC TGNDTHPESM LFEMNGYLDS AIHSNSTIKH
     IILYLNNFPC NEANHCCISK MYNFLMMYPD ITLSIYFSQL YHTKSEFPTS AWNREALRSL
     ASLWPQVTLS PISGMIWHSL LNNFVMGVSG PAAFQPILTG RALADRHNAY EISAITGVKP
     YFTDVLPQTK ANQNIKAQVA SGSYPLSNVF AGQSFQGTKG QLQHNLTPDL RIPVVFVLVP
     YRDLPPTQVG QNLHKPRHVV RHLNMPQMSI YENKDSKNFP SED
//