ID G5B572_HETGA Unreviewed; 105 AA.
AC G5B572;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial {ECO:0000256|ARBA:ARBA00014585};
DE AltName: Full=Complex I-AGGG {ECO:0000256|ARBA:ARBA00031368};
DE AltName: Full=NADH-ubiquinone oxidoreductase AGGG subunit {ECO:0000256|ARBA:ARBA00031736};
GN ORFNames=GW7_11848 {ECO:0000313|EMBL:EHB04433.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB04433.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB04433.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC chain NADH dehydrogenase (Complex I), that is believed not to be
CC involved in catalysis. Complex I functions in the transfer of electrons
CC from NADH to the respiratory chain. The immediate electron acceptor for
CC the enzyme is believed to be ubiquinone.
CC {ECO:0000256|ARBA:ARBA00003195}.
CC -!- SUBUNIT: Complex I is composed of 45 different subunits.
CC {ECO:0000256|ARBA:ARBA00011533}.
CC -!- SIMILARITY: Belongs to the complex I NDUFB2 subunit family.
CC {ECO:0000256|ARBA:ARBA00005923}.
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DR EMBL; JH168530; EHB04433.1; -; Genomic_DNA.
DR RefSeq; XP_004851341.1; XM_004851284.2.
DR AlphaFoldDB; G5B572; -.
DR STRING; 10181.G5B572; -.
DR GeneID; 101702077; -.
DR KEGG; hgl:101702077; -.
DR CTD; 4708; -.
DR eggNOG; ENOG502S524; Eukaryota.
DR InParanoid; G5B572; -.
DR OMA; HLWHDPD; -.
DR OrthoDB; 5402335at2759; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR Bgee; ENSHGLG00000017933; Expressed in heart and 10 other cell types or tissues.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IEA:InterPro.
DR InterPro; IPR026627; NDUFB2_animal.
DR PANTHER; PTHR15223:SF1; NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 2, MITOCHONDRIAL; 1.
DR PANTHER; PTHR15223; NADH-UBIQUINONE OXIDOREDUCTASE AGGG SUBUNIT; 1.
DR Pfam; PF14813; NADH_B2; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Transit peptide {ECO:0000256|ARBA:ARBA00022946};
KW Transport {ECO:0000256|ARBA:ARBA00022448};
KW Ubiquinone {ECO:0000313|EMBL:EHB04433.1}.
SQ SEQUENCE 105 AA; 12024 MW; 7E2FB2053E1A4B1B CRC64;
MSALTWLVPF SRVGGRLFRG YRARAAGGSG VRHAAGGAHA QPYYRAFPQP TRYEVIRAEV
LSGFMWFWIL WHFWHDSEAV LGHFTYPDPS QWTDEELGIP PDDED
//
