ID G5B592_HETGA Unreviewed; 495 AA.
AC G5B592;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 61.
DE SubName: Full=Potassium voltage-gated channel subfamily F member 1 {ECO:0000313|EMBL:EHB04453.1};
GN ORFNames=GW7_13025 {ECO:0000313|EMBL:EHB04453.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB04453.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB04453.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; JH168584; EHB04453.1; -; Genomic_DNA.
DR RefSeq; XP_004870005.1; XM_004869948.1.
DR AlphaFoldDB; G5B592; -.
DR STRING; 10181.G5B592; -.
DR Ensembl; ENSHGLT00000005276; ENSHGLP00000033498; ENSHGLG00000003808.
DR Ensembl; ENSHGLT00000047450; ENSHGLP00000050522; ENSHGLG00000003808.
DR Ensembl; ENSHGLT00000082546; ENSHGLP00000034919; ENSHGLG00000003808.
DR GeneID; 101725666; -.
DR KEGG; hgl:101725666; -.
DR CTD; 3754; -.
DR eggNOG; KOG3713; Eukaryota.
DR InParanoid; G5B592; -.
DR OMA; FKCIIDV; -.
DR OrthoDB; 1478695at2759; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0097546; C:ciliary base; IEA:Ensembl.
DR GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR GO; GO:1905515; P:non-motile cilium assembly; IEA:Ensembl.
DR GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR CDD; cd18381; BTB_POZ_Kv5_KCNF1; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003968; K_chnl_volt-dep_Kv.
DR InterPro; IPR003971; K_chnl_volt-dep_Kv9.
DR InterPro; IPR048010; KCNF1-like_BTB_POZ.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR003131; T1-type_BTB.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR11537:SF171; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY F MEMBER 1; 1.
DR PANTHER; PTHR11537; VOLTAGE-GATED POTASSIUM CHANNEL; 1.
DR Pfam; PF02214; BTB_2; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR PRINTS; PR00169; KCHANNEL.
DR PRINTS; PR01494; KV9CHANNEL.
DR PRINTS; PR01491; KVCHANNEL.
DR SUPFAM; SSF54695; POZ domain; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 184..205
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 249..271
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 325..342
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 386..407
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 26..127
FT /note="Potassium channel tetramerisation-type BTB"
FT /evidence="ECO:0000259|Pfam:PF02214"
FT DOMAIN 183..417
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 434..471
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 476..495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 479..495
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 495 AA; 55789 MW; 71345E18EE121CC9 CRC64;
MDGARERSLA EPDSRGSAAT GEDIEIVVNV GGVRQVLYGD LLSQYPETRL AELINCLAGG
YDTIFSLCDD YDPGKREFYF DRDPDAFKCV VEVYYFGEVH MKKGICPICF KNEMEFWKVD
LRFLDDCCKS HLSEKREELE EIARRVQLIL DDLGVDAAEG RWRCCQKRVW KFLEKPESSC
PARVVAVLSF LLILVSSVVM CMGTIPELQV VDSEGNRVEH PTLENVETAC IGWFTLEYLL
RLFSSPNKLH FALSFMNIVD VLAILPFYVS LTLTHLGARM MELTNVQQAV QALRIMRIAR
IFKLARHSSG LQTLTYALKR SFKELGLLLM YLAVGIFVFS ALGYTMEQSH PETLFKSIPQ
SFWWAIITMT TVGYGDIYPK TTLGKLNAAI SFLCGVIAIA LPIHPIINNF VRYYNKQRVL
ETAAKHELEL MELNSGSAGD SKPGGSRSDL DTLPPEPAGK EAPSWGSRLK LSHSDTSIPL
LTEEKHHRTR IQSCK
//
