ID G5B5F7_HETGA Unreviewed; 1337 AA.
AC G5B5F7;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE RecName: Full=phosphoribosylformylglycinamidine synthase {ECO:0000256|ARBA:ARBA00012747};
DE EC=6.3.5.3 {ECO:0000256|ARBA:ARBA00012747};
DE AltName: Full=Formylglycinamide ribonucleotide amidotransferase {ECO:0000256|ARBA:ARBA00032632};
DE AltName: Full=Formylglycinamide ribotide amidotransferase {ECO:0000256|ARBA:ARBA00029823};
GN ORFNames=GW7_13859 {ECO:0000313|EMBL:EHB04518.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB04518.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB04518.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-
CC amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-
CC phospho-D-ribosyl)glycinamide: step 1/2.
CC {ECO:0000256|ARBA:ARBA00004920}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the FGAMS family.
CC {ECO:0000256|ARBA:ARBA00008608}.
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DR EMBL; JH168588; EHB04518.1; -; Genomic_DNA.
DR STRING; 10181.G5B5F7; -.
DR eggNOG; KOG1907; Eukaryota.
DR InParanoid; G5B5F7; -.
DR UniPathway; UPA00074; UER00128.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004642; F:phosphoribosylformylglycinamidine synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd01740; GATase1_FGAR_AT; 1.
DR CDD; cd02203; PurL_repeat1; 1.
DR CDD; cd02204; PurL_repeat2; 1.
DR Gene3D; 3.40.50.880; -; 1.
DR Gene3D; 1.10.8.750; Phosphoribosylformylglycinamidine synthase, linker domain; 1.
DR Gene3D; 3.90.650.10; PurM-like C-terminal domain; 2.
DR Gene3D; 3.30.1330.10; PurM-like, N-terminal domain; 2.
DR HAMAP; MF_00419; PurL_1; 1.
DR InterPro; IPR029062; Class_I_gatase-like.
DR InterPro; IPR040707; FGAR-AT_N.
DR InterPro; IPR010073; PurL_large.
DR InterPro; IPR041609; PurL_linker.
DR InterPro; IPR010918; PurM-like_C_dom.
DR InterPro; IPR036676; PurM-like_C_sf.
DR InterPro; IPR036921; PurM-like_N_sf.
DR InterPro; IPR036604; PurS-like_sf.
DR NCBIfam; TIGR01735; FGAM_synt; 1.
DR PANTHER; PTHR10099; PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE; 1.
DR PANTHER; PTHR10099:SF1; PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE; 1.
DR Pfam; PF02769; AIRS_C; 2.
DR Pfam; PF18072; FGAR-AT_linker; 1.
DR Pfam; PF18076; FGAR-AT_N; 1.
DR Pfam; PF13507; GATase_5; 1.
DR SMART; SM01211; GATase_5; 1.
DR SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 1.
DR SUPFAM; SSF109736; FGAM synthase PurL, linker domain; 1.
DR SUPFAM; SSF56042; PurM C-terminal domain-like; 2.
DR SUPFAM; SSF55326; PurM N-terminal domain-like; 2.
DR SUPFAM; SSF82697; PurS-like; 1.
DR PROSITE; PS51273; GATASE_TYPE_1; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Glutamine amidotransferase {ECO:0000256|ARBA:ARBA00022962,
KW ECO:0000256|PROSITE-ProRule:PRU00605};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Purine biosynthesis {ECO:0000256|ARBA:ARBA00022755};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813}.
FT DOMAIN 83..155
FT /note="Phosphoribosylformylglycinamidine synthase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF18076"
FT DOMAIN 184..232
FT /note="Phosphoribosylformylglycinamidine synthase linker"
FT /evidence="ECO:0000259|Pfam:PF18072"
FT DOMAIN 444..602
FT /note="PurM-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02769"
FT DOMAIN 876..975
FT /note="PurM-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02769"
FT REGION 604..624
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 1158
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
FT ACT_SITE 1297
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
FT ACT_SITE 1299
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
SQ SEQUENCE 1337 AA; 144206 MW; 9EE401464B660B23 CRC64;
MAPVLRFYVR PSGHEGAASG QSVRKLQEKL PELERVETEL CYNVNWTAEA VPSTLEMKKL
KWLFGCPLFL DDVAQESWLR PGSNDLLLEV GPRLNFSTPT STNIVSVCQA AGLVAVNRVE
PTRRYQLSFA RRPSAEMKAM ALAALHDRMT EQHFPHPIQS FLPESTPAPL SGPINILQEG
RSALEKANQK LGLALDSWDL DFYTKRFQEL QRNPSTVEAF DLAQSNSEHS RHWFFKGQLH
VDGKKLLHSL FESIMSTQAS SNPNNVLKFC DNSSAIQGKE VRFLQPEDPI KPSCFRQQQR
LRHVVFTAET HNFPTGVSPF SGATTGTGGR IRDVQCTGRG AHVVAGTAGY CFGNLCIPGY
SLPWEDPSFQ YPGNFARPLE IAIEASNGAS DYGNKFGEPV LAGFARSLGL QLPDGQRREW
IKPIMFSGGI GSMEAEHVGK QPPEPGMEVV KVGGPVYRIG VGGGAASSVQ VQGDNSSDLD
FGAVQRGDPE MEQKMNRVIR ACVEAPRGNP ICSLHDQGAG GNGNVLKELS DPAGAIIYTS
RFQLGDPTLN ALEIWGAEYQ ESNALLLRPP HRDFLSCVSA RERCPASFVG TITGDKRIVL
VDDRESPVGV NDQGDAPTAP PPTPVDLELD WVLGKMPRKE FFLQREPPVL QPLALPPGLT
VRQALERVLR LPAVASKRYL TNKVDRSVGG LVAQQQCVGP LQTPLADVAV MALSHQELIG
AATALGEQPV KSLLDPKVAA RLAVAEALTN LVFALVTDLR DVKCSGNWMW AAKLPGEGAA
LVDACEAMVA VMAALGVAVD GGKDSLSMAA RVGSETVRAP GALVISAYAV CPDITATVTP
DLKHPEGRGH LLYVPLSPGQ YRLGGTALAQ CFSQLGEQPP DLDLPENLVR AFSITQGLLK
DRLLCSGHDV SDGGLVTCLL EMAFAGNCGI EVDVPAPGVD ALPVLFAEEP GLVLEVQEPN
LAGVLQRYRG AGLCCLDLGC TGEAGPHAMV RVSVNGVVAM EEAVGQLRAL WEETSFQLDR
LQAEPHCVAE EEQGLKERMG PNYCLPPTFP KASVPREPGS PSLRVAILRE EGSNGDREMA
DAFHLAGFEV WDVTMQDLCS GAIGLDTFRG VAFVGGFSYA DVLGSAKGWA AAVTFNPKAR
AELSRFRKRP DTFSLGVCNG CQLLALLGWV GSDTNEEAGD LGHDSWPAQP SLLLCHNLSG
RYESRWASVR VGPGPALMLR GMEGAVLPVW SAHGEGYMAF SSPELQAQME ASGFVSLHWA
DDDGNPTERY PLNPNGSPGG MAGICSCDGR HLALMPHPER AVRPWQWAWR PSPFDTLTTS
PWLQLFINAQ DWAQGGC
//
