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Database: UniProt
Entry: G5B6T4_HETGA
LinkDB: G5B6T4_HETGA
Original site: G5B6T4_HETGA 
ID   G5B6T4_HETGA            Unreviewed;      1032 AA.
AC   G5B6T4;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   24-JAN-2024, entry version 39.
DE   RecName: Full=Presequence protease, mitochondrial {ECO:0000256|ARBA:ARBA00020167};
DE   AltName: Full=Pitrilysin metalloproteinase 1 {ECO:0000256|ARBA:ARBA00032857};
GN   ORFNames=GW7_21507 {ECO:0000313|EMBL:EHB04995.1};
OS   Heterocephalus glaber (Naked mole rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC   Heterocephalus.
OX   NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB04995.1, ECO:0000313|Proteomes:UP000006813};
RN   [1] {ECO:0000313|EMBL:EHB04995.1, ECO:0000313|Proteomes:UP000006813}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993625; DOI=10.1038/nature10533;
RA   Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA   Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA   Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA   Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA   Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA   Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT   "Genome sequencing reveals insights into physiology and longevity of the
RT   naked mole rat.";
RL   Nature 479:223-227(2011).
CC   -!- SUBUNIT: Monomer and homodimer; homodimerization is induced by binding
CC       of the substrate. {ECO:0000256|ARBA:ARBA00011853}.
CC   -!- SIMILARITY: Belongs to the peptidase M16 family. PreP subfamily.
CC       {ECO:0000256|ARBA:ARBA00007575}.
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DR   EMBL; JH168671; EHB04995.1; -; Genomic_DNA.
DR   AlphaFoldDB; G5B6T4; -.
DR   STRING; 10181.G5B6T4; -.
DR   eggNOG; KOG2019; Eukaryota.
DR   InParanoid; G5B6T4; -.
DR   Proteomes; UP000006813; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR   InterPro; IPR011249; Metalloenz_LuxS/M16.
DR   InterPro; IPR011765; Pept_M16_N.
DR   InterPro; IPR007863; Peptidase_M16_C.
DR   InterPro; IPR013578; Peptidase_M16C_assoc.
DR   PANTHER; PTHR43016; PRESEQUENCE PROTEASE; 1.
DR   PANTHER; PTHR43016:SF13; PRESEQUENCE PROTEASE, MITOCHONDRIAL; 1.
DR   Pfam; PF08367; M16C_assoc; 1.
DR   Pfam; PF00675; Peptidase_M16; 1.
DR   Pfam; PF05193; Peptidase_M16_C; 2.
DR   SMART; SM01264; M16C_associated; 1.
DR   SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000313|EMBL:EHB04995.1};
KW   Protease {ECO:0000313|EMBL:EHB04995.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006813}.
FT   DOMAIN          504..752
FT                   /note="Peptidase M16C associated"
FT                   /evidence="ECO:0000259|SMART:SM01264"
FT   REGION          806..830
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1032 AA;  117007 MW;  99B18BB1A531A81D CRC64;
     MWRYGGRRTL GAVQRLSSCS THHKVWRWSS SKACERALQY NVGEKIHGFT VEQVTSVPEL
     LLTAVKLSHD NTGARYLHLA REDTNNLFSV QFRTTPMDST GVPHVLEHTV LCGSQKYPCR
     DPFFKMLNRS LSTFMNAFTA SDYTLYPFST QNAKDFQNLL SVYLDATFFP CLRELDFWQE
     GWRLEHVNPS DPQTPLIFKG VVFNEMKGAF VNNERIFSQN LQNKLLPDHT YSVISGGDPL
     CIPELTWEQL KQFHATHYHP SNARFFTYGN FELQQHLKQI HEEALSKFQK IEPSTVVPAQ
     QPWDKPREFQ ITCGPDSLTT DASKQTTVSV SFLLPDITDI FEAFTLNLLS SLLISGPNSP
     FYKALIESGI GTDFSPDVGY NGNTREAYFS VGLQGIAEKD IQIVRDLVNK TIHEVVEKGF
     ENEQIEALLH KIEIQMKHQT TNFGLTLTSY IASCWNHDGD PVELLQMGSQ LAKFRQCLKE
     NPEFLQEKVK QYFKNNQHKL TLSMKPDDKY YEKQSEMETE KLEQKVSSLS QNDKQQIYEK
     GLELRDQQSK PQDASCLPAL KVLDIEPTMP FTEVEVALAA GEIPVQYCAQ PTNGVVYFRA
     FSNLNTLSEE LKPYVPLFCT VLTKLGCGNL NYREQAQQIE LKTGGMTVSP QVLPDESHLD
     TYEQGVLFSS LCLDRNLPDM MHLWTEIFNH PSFEEEEHFK VLVKMTAQEL SNGIPDSGHV
     YASLRASKTL TPVGDLQETF SGMDQVRLMK RIAEMTDITP VLKMFPRVKK HLLKCDNLRC
     SVNATPHQMS QAEKEVENFI RSLPRSKKER KPVRPHVIEK PVPSGSGADG SQMIRKLITE
     PTFKPWQMKT HLLMPFPVNY IGECVRTVPY AHPDHASLKI LARLMTAKFL HTEIREKGGA
     YGGGAKLGYN GIFTFYSYRD PNSIETLQSF EKAVDWAKSG NFTQQDIDEA KLSIFSAVDA
     PVAPSDKGLD HFLHGLSNEM KQMHREQLFA VSLDSLTAVS DKYLGVGKST HGLAIVGPEN
     EKISKDPSWI VK
//
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