ID G5B6T4_HETGA Unreviewed; 1032 AA.
AC G5B6T4;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE RecName: Full=Presequence protease, mitochondrial {ECO:0000256|ARBA:ARBA00020167};
DE AltName: Full=Pitrilysin metalloproteinase 1 {ECO:0000256|ARBA:ARBA00032857};
GN ORFNames=GW7_21507 {ECO:0000313|EMBL:EHB04995.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB04995.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB04995.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SUBUNIT: Monomer and homodimer; homodimerization is induced by binding
CC of the substrate. {ECO:0000256|ARBA:ARBA00011853}.
CC -!- SIMILARITY: Belongs to the peptidase M16 family. PreP subfamily.
CC {ECO:0000256|ARBA:ARBA00007575}.
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DR EMBL; JH168671; EHB04995.1; -; Genomic_DNA.
DR AlphaFoldDB; G5B6T4; -.
DR STRING; 10181.G5B6T4; -.
DR eggNOG; KOG2019; Eukaryota.
DR InParanoid; G5B6T4; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR007863; Peptidase_M16_C.
DR InterPro; IPR013578; Peptidase_M16C_assoc.
DR PANTHER; PTHR43016; PRESEQUENCE PROTEASE; 1.
DR PANTHER; PTHR43016:SF13; PRESEQUENCE PROTEASE, MITOCHONDRIAL; 1.
DR Pfam; PF08367; M16C_assoc; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 2.
DR SMART; SM01264; M16C_associated; 1.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:EHB04995.1};
KW Protease {ECO:0000313|EMBL:EHB04995.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813}.
FT DOMAIN 504..752
FT /note="Peptidase M16C associated"
FT /evidence="ECO:0000259|SMART:SM01264"
FT REGION 806..830
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1032 AA; 117007 MW; 99B18BB1A531A81D CRC64;
MWRYGGRRTL GAVQRLSSCS THHKVWRWSS SKACERALQY NVGEKIHGFT VEQVTSVPEL
LLTAVKLSHD NTGARYLHLA REDTNNLFSV QFRTTPMDST GVPHVLEHTV LCGSQKYPCR
DPFFKMLNRS LSTFMNAFTA SDYTLYPFST QNAKDFQNLL SVYLDATFFP CLRELDFWQE
GWRLEHVNPS DPQTPLIFKG VVFNEMKGAF VNNERIFSQN LQNKLLPDHT YSVISGGDPL
CIPELTWEQL KQFHATHYHP SNARFFTYGN FELQQHLKQI HEEALSKFQK IEPSTVVPAQ
QPWDKPREFQ ITCGPDSLTT DASKQTTVSV SFLLPDITDI FEAFTLNLLS SLLISGPNSP
FYKALIESGI GTDFSPDVGY NGNTREAYFS VGLQGIAEKD IQIVRDLVNK TIHEVVEKGF
ENEQIEALLH KIEIQMKHQT TNFGLTLTSY IASCWNHDGD PVELLQMGSQ LAKFRQCLKE
NPEFLQEKVK QYFKNNQHKL TLSMKPDDKY YEKQSEMETE KLEQKVSSLS QNDKQQIYEK
GLELRDQQSK PQDASCLPAL KVLDIEPTMP FTEVEVALAA GEIPVQYCAQ PTNGVVYFRA
FSNLNTLSEE LKPYVPLFCT VLTKLGCGNL NYREQAQQIE LKTGGMTVSP QVLPDESHLD
TYEQGVLFSS LCLDRNLPDM MHLWTEIFNH PSFEEEEHFK VLVKMTAQEL SNGIPDSGHV
YASLRASKTL TPVGDLQETF SGMDQVRLMK RIAEMTDITP VLKMFPRVKK HLLKCDNLRC
SVNATPHQMS QAEKEVENFI RSLPRSKKER KPVRPHVIEK PVPSGSGADG SQMIRKLITE
PTFKPWQMKT HLLMPFPVNY IGECVRTVPY AHPDHASLKI LARLMTAKFL HTEIREKGGA
YGGGAKLGYN GIFTFYSYRD PNSIETLQSF EKAVDWAKSG NFTQQDIDEA KLSIFSAVDA
PVAPSDKGLD HFLHGLSNEM KQMHREQLFA VSLDSLTAVS DKYLGVGKST HGLAIVGPEN
EKISKDPSWI VK
//