ID G5B721_HETGA Unreviewed; 467 AA.
AC G5B721;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Dynactin subunit 4 {ECO:0000256|ARBA:ARBA00034864};
GN ORFNames=GW7_12577 {ECO:0000313|EMBL:EHB05082.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB05082.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB05082.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cell cortex
CC {ECO:0000256|ARBA:ARBA00004544}. Cytoplasm, cytoskeleton, microtubule
CC organizing center, centrosome {ECO:0000256|ARBA:ARBA00004300}.
CC Cytoplasm, cytoskeleton, stress fiber {ECO:0000256|ARBA:ARBA00004529}.
CC Cytoplasm, myofibril, sarcomere {ECO:0000256|ARBA:ARBA00004204}.
CC -!- SIMILARITY: Belongs to the dynactin subunit 4 family.
CC {ECO:0000256|ARBA:ARBA00034776}.
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DR EMBL; JH168688; EHB05082.1; -; Genomic_DNA.
DR RefSeq; XP_004854490.1; XM_004854433.2.
DR AlphaFoldDB; G5B721; -.
DR STRING; 10181.G5B721; -.
DR Ensembl; ENSHGLT00000064577; ENSHGLP00000029148; ENSHGLG00000050283.
DR GeneID; 101697514; -.
DR KEGG; hgl:101697514; -.
DR CTD; 51164; -.
DR eggNOG; KOG3896; Eukaryota.
DR InParanoid; G5B721; -.
DR OMA; IYFCRHC; -.
DR OrthoDB; 5483333at2759; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR Bgee; ENSHGLG00000006565; Expressed in pituitary gland and 10 other cell types or tissues.
DR GO; GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005869; C:dynactin complex; IEA:InterPro.
DR GO; GO:0030017; C:sarcomere; IEA:UniProtKB-SubCell.
DR GO; GO:0001725; C:stress fiber; IEA:UniProtKB-SubCell.
DR InterPro; IPR008603; DCTN4.
DR PANTHER; PTHR13034; DYNACTIN P62 SUBUNIT; 1.
DR PANTHER; PTHR13034:SF2; DYNACTIN SUBUNIT 4; 1.
DR Pfam; PF05502; Dynactin_p62; 2.
PE 3: Inferred from homology;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813}.
SQ SEQUENCE 467 AA; 53129 MW; E8F5BFEBC1AFF7A4 CRC64;
MASLLQSERV LYLVQGEKKV RAPLSQLYFC RYCSELRSLE CVSHEVDSHY CPSCLENMPS
AEAKLKKNRC ANCFDCPGCM HTLSTRATSI STQLPDDPAK TAMKKAYYLA CGFCRWTSRD
VGMADKSVAS GGWQEPENPH TQRMNKLIEY YQQLAQKEKV ERDRKKLARR RNYMPLAFSQ
HTIHVVDKYG LGTRLQRPRA GASISTLAGL SLKEGEDQKE IKIEPAQAVD EVEPLPEDYY
TRPVNLTEVT TLQQRLLQPD FQPICASQLY PRHKHLLIKR SLRCRKCEHN LSKPEFNPTS
IKFKIQLVAV NYIPEVRIMS IPNLRYTKES QVLLTLTNPV ENLTHVTLLE CEEGDPDKTN
STAKVVVPPR ELVLAGKDAA AEYDELAEPQ DFQDDPDIIA FRKANKVGIF IKVTPQREEG
EVTVCFKMKH DFKNLAAPIR PIEESDQATE VIWLTQHVEL SLGPLLP
//
