ID G5B794_HETGA Unreviewed; 783 AA.
AC G5B794;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Neuronal PAS domain-containing protein 2 {ECO:0000313|EMBL:EHB05155.1};
GN ORFNames=GW7_13241 {ECO:0000313|EMBL:EHB05155.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB05155.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB05155.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
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DR EMBL; JH168769; EHB05155.1; -; Genomic_DNA.
DR AlphaFoldDB; G5B794; -.
DR STRING; 10181.G5B794; -.
DR eggNOG; KOG3561; Eukaryota.
DR InParanoid; G5B794; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0032922; P:circadian regulation of gene expression; IEA:InterPro.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR047230; CLOCK-like.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR001067; Nuc_translocat.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR46055; CIRCADIAN LOCOMOTER OUTPUT CYCLES PROTEIN KAPUT; 1.
DR PANTHER; PTHR46055:SF1; NEURONAL PAS DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF14598; PAS_11; 1.
DR PRINTS; PR00785; NCTRNSLOCATR.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00086; PAC; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 2.
PE 4: Predicted;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Biological rhythms {ECO:0000256|ARBA:ARBA00023108};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 9..59
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 82..154
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 222..269
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 337..405
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 577..605
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 651..672
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 740..783
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 353..405
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 577..603
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 783 AA; 86203 MW; 8E486F110E26581B CRC64;
MRVRLSFSEL GASRNKSEKK RRDQFNVLIK ELSSMLPGNT RKMDKTTVLE KVIGFLQKHN
EVSAQTEICD IQQDWKPSFL SNEEFTQLML EALDGFIIVV TTDGSILYVS DSITPLLGHL
PSDVMDQNLL NFLPEQEHSE VYKMLSSHML LTDSPSPEFL KLPSPSCNSF NNALSRPCRV
PLGEEVCFIA TVRLATPQFL KEMCIVDEPL EEFTSRHSLE WKFLFLDHRA PPIIGYLPFE
VLGTSGYDYY HIDDLELLAR CHQHLMQFGK GKSCCYRFLT KGQQWIWLQT HYYITYHQWN
SKPEFIVCTH SVVSVLSGVL SSYADVRVER RQELALEDPP PEVLHPSVLK DKGSSLDPQQ
HCTTLDTGAP GLNASPSPSV SSRSSHKSTH TAMSEPASTP TKLMAEASTT SLPRLATLPQ
ELPVPGLSQV ATMPAPLPSP ASCDLTQQLL PQTILQSPPA PMAQFSAQLS MFQTIKDQLE
QRTRVLQANI RWQQEELHKI QEQLCLVQDS SVQMFLQQPA VSLSFSSAQQ PEAQQQLPQR
VAGAAQPQLM TSPQLPGQMA SAQVTSQHLL RESTVIASQG LKPMRSPQVM QGSSRSASSL
PPPFGSTAAL LPPALSLAAP VPTSQDASQC QPGPDFSHDQ QLRLLLSQPI QPMMPGSCDS
RAPAEASRTG QHVKFAPSQA EFPSPDSHPA SSSAVTPVLL MGQTVLHPSF PASQPAQQLQ
LNYLQAPTSL HSEQPDSLLL STYSQQPGTL GYAPPSSAQP QPTRPSRRVS RLSESSGLQQ
PPG
//
