ID G5B7J1_HETGA Unreviewed; 953 AA.
AC G5B7J1;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 55.
DE SubName: Full=Putative ATP-dependent RNA helicase DDX11-like protein {ECO:0000313|EMBL:EHB05252.1};
GN ORFNames=GW7_07380 {ECO:0000313|EMBL:EHB05252.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB05252.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB05252.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC DDX11/CHL1 sub-subfamily. {ECO:0000256|ARBA:ARBA00008435}.
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DR EMBL; JH168787; EHB05252.1; -; Genomic_DNA.
DR AlphaFoldDB; G5B7J1; -.
DR STRING; 10181.G5B7J1; -.
DR eggNOG; KOG1133; Eukaryota.
DR InParanoid; G5B7J1; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016818; F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; IEA:InterPro.
DR GO; GO:0006139; P:nucleobase-containing compound metabolic process; IEA:InterPro.
DR CDD; cd18788; SF2_C_XPD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR006555; ATP-dep_Helicase_C.
DR InterPro; IPR045028; DinG/Rad3-like.
DR InterPro; IPR014013; Helic_SF1/SF2_ATP-bd_DinG/Rad3.
DR InterPro; IPR006554; Helicase-like_DEXD_c2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010614; RAD3-like_helicase_DEAD.
DR InterPro; IPR013020; Rad3/Chl1-like.
DR NCBIfam; TIGR00604; rad3; 1.
DR PANTHER; PTHR11472:SF41; ATP-DEPENDENT DNA HELICASE DDX11-RELATED; 1.
DR PANTHER; PTHR11472; DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER; 1.
DR Pfam; PF06733; DEAD_2; 1.
DR Pfam; PF13307; Helicase_C_2; 2.
DR SMART; SM00488; DEXDc2; 1.
DR SMART; SM00491; HELICc2; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51193; HELICASE_ATP_BIND_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:EHB05252.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813}.
FT DOMAIN 26..470
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51193"
FT REGION 96..129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 147..183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 323..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 114..128
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 147..166
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 953 AA; 105741 MW; FF60434459F84F58 CRC64;
MKALDEMHDS AVGSCRTMAD KTQEVGGIHF PFPFPPYSIQ KDFMAELYQV LEAGKIGIFE
SPTGTGKSLS LICGALSWLR DFEQKKQQEE VRCLLDPGAG PLPEGRDLRP EASSSCHASP
TTSRPAGEPD WVTQFVQRKE ERDLAERVKD EQIRRRKREE RLQQTRHSAQ LKYAARGRRQ
EEEETEALLR LSREMLAEGA GAEQLEQLEP GEEELVLAEY TSDEERRAAS GSRELSCQPE
PCGAQGPTVK ASLLLVLLLL QAPVDEDEED LEEEHVTKIY YCSRTHSQLA QFVQENLCVN
EDVRSLGSVQ LINDRCVEIQ RSQHKSKSRA EEEKPKRRRQ EARAACPFYN HEQMQLLRDE
ILVEVRDVEQ LVALGKEARA CPYYGSRLAI AAAQLVVLPY PTRQAAGIRL QGQVVIIDEA
HNLIDTITGI HSVEVTGSQL CQAHSQLLQY TERYRKRLKA KNLMYIKQIL YLLEKFVAVL
GGDIRQNPNT RSLSQTGTEL KTINDFLFES QVDNINLFKV QRYCEKSKVS RKLCGFTERY
GAVLPPPQQQ SRLAGLQHFL QSLQPSTTEA PAAPLEEAEP GAVRAASPLM HVEGFLSALT
TANQDGRVIL SRQGSLSQSS LKFLLLNPAV HFAQVVKECR AVVIAGGTMQ PVSDFREQLL
ACAGVEAERV VEFSCGHVIP PDNILPLVLC SGPTNQQLEF TYQKREVPAM MDEAGRILCN
LCNVVPGGLV CFFPSYEYQH QVLAHWGKSG LLTRLAVRKK IFQEPKRAGQ VEQVLAAYAR
CIESCARASG PGTGALLLAV VGGKMSEGIN FSDDLGRCVV MVGMPYPSIR APELQEKMAY
LDQRLPGTPG QVPPGKALVE NLCMKAVNQS VGEPGAVLAL DAQPGTDGQR GGGRAIRHQR
DFASIVLLDQ RYARPPVLAK LPAWIRDRVE VKATFGAAFA ALRKFHREKV GPS
//
