ID G5B825_HETGA Unreviewed; 102 AA.
AC G5B825;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE RecName: Full=Somatoliberin {ECO:0000256|ARBA:ARBA00040782};
DE AltName: Full=Growth hormone-releasing factor {ECO:0000256|ARBA:ARBA00042164};
DE AltName: Full=Growth hormone-releasing hormone {ECO:0000256|ARBA:ARBA00041953};
DE Flags: Fragment;
GN ORFNames=GW7_21250 {ECO:0000313|EMBL:EHB05436.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB05436.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB05436.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- FUNCTION: GRF is released by the hypothalamus and acts on the
CC adenohypophyse to stimulate the secretion of growth hormone.
CC {ECO:0000256|ARBA:ARBA00037623}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the glucagon family.
CC {ECO:0000256|ARBA:ARBA00008369}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JH168905; EHB05436.1; -; Genomic_DNA.
DR AlphaFoldDB; G5B825; -.
DR STRING; 10181.G5B825; -.
DR eggNOG; ENOG502S2N6; Eukaryota.
DR InParanoid; G5B825; -.
DR OMA; DSVWTDQ; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005184; F:neuropeptide hormone activity; IEA:InterPro.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IEA:UniProt.
DR GO; GO:0032879; P:regulation of localization; IEA:UniProt.
DR InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR InterPro; IPR046963; VIP/GHRH-like.
DR PANTHER; PTHR11213; GLUCAGON-FAMILY NEUROPEPTIDE; 1.
DR PANTHER; PTHR11213:SF6; SOMATOLIBERIN; 1.
DR Pfam; PF00123; Hormone_2; 1.
DR SMART; SM00070; GLUCA; 1.
DR PROSITE; PS00260; GLUCAGON; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..102
FT /note="Somatoliberin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003474121"
FT DOMAIN 32..54
FT /note="Glucagon / GIP / secretin / VIP family"
FT /evidence="ECO:0000259|PROSITE:PS00260"
FT NON_TER 102
FT /evidence="ECO:0000313|EMBL:EHB05436.1"
SQ SEQUENCE 102 AA; 11852 MW; 2C566F5670790543 CRC64;
MPLWVFFFVI LTLSSSSHCS SPVSLPLRMR RYADAIFTNS YRKVLSQLSA RKLLQDIMNR
QQGKRNQEQG ARIRLGRQLD SMWTDQNQVA LESMLVALLQ KH
//