ID G5B8F2_HETGA Unreviewed; 397 AA.
AC G5B8F2;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Vacuolar protein sorting-associated protein 37A {ECO:0000313|EMBL:EHB05563.1, ECO:0000313|EMBL:JAO01105.1};
GN Name=VPS37A {ECO:0000313|EMBL:JAO01105.1};
GN ORFNames=GW7_20345 {ECO:0000313|EMBL:EHB05563.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB05563.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB05563.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
RN [2] {ECO:0000313|EMBL:JAO01105.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Kidney {ECO:0000313|EMBL:JAO01105.1};
RA Bens M., Sahm A., Jahn N., Morhart M., Holtze S., Hildebrandt T.B.,
RA Platzer M., Szafranski K.;
RT "FRAMA: From RNA-seq data to annotated mRNA assemblies.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the ESCRT-I complex, a regulator of vesicular
CC trafficking process. Required for the sorting of endocytic
CC ubiquitinated cargos into multivesicular bodies. May be involved in
CC cell growth and differentiation. {ECO:0000256|ARBA:ARBA00025010}.
CC -!- SUBCELLULAR LOCATION: Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}. Late endosome membrane
CC {ECO:0000256|ARBA:ARBA00004633}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004633}.
CC -!- SIMILARITY: Belongs to the VPS37 family.
CC {ECO:0000256|ARBA:ARBA00007617}.
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DR EMBL; JH168947; EHB05563.1; -; Genomic_DNA.
DR EMBL; GEBF01002528; JAO01105.1; -; Transcribed_RNA.
DR RefSeq; XP_004853143.1; XM_004853086.2.
DR AlphaFoldDB; G5B8F2; -.
DR STRING; 10181.G5B8F2; -.
DR GeneID; 101700435; -.
DR KEGG; hgl:101700435; -.
DR CTD; 137492; -.
DR eggNOG; KOG3270; Eukaryota.
DR InParanoid; G5B8F2; -.
DR OMA; HPWCNEH; -.
DR OrthoDB; 3677578at2759; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR Bgee; ENSHGLG00000006804; Expressed in heart and 10 other cell types or tissues.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0000813; C:ESCRT I complex; IEA:Ensembl.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0043162; P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; IEA:Ensembl.
DR Gene3D; 1.10.287.660; Helix hairpin bin; 1.
DR Gene3D; 3.10.110.10; Ubiquitin Conjugating Enzyme; 1.
DR InterPro; IPR037202; ESCRT_assembly_dom.
DR InterPro; IPR029012; Helix_hairpin_bin_sf.
DR InterPro; IPR009851; Mod_r.
DR InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR PANTHER; PTHR13678; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37; 1.
DR PANTHER; PTHR13678:SF2; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37A; 1.
DR Pfam; PF07200; Mod_r; 1.
DR SUPFAM; SSF140111; Endosomal sorting complex assembly domain; 1.
DR SUPFAM; SSF54495; UBC-like; 1.
DR PROSITE; PS51314; VPS37_C; 1.
PE 3: Inferred from homology;
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 308..397
FT /note="VPS37 C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51314"
SQ SEQUENCE 397 AA; 44403 MW; D625C636A351E28A CRC64;
MSWLFPLTKS AASSAAGAPS GLTSLQQQKQ RLIESLRNSH SSIAEIQKDV EYRLPFTVNN
LTININILLP PQFPQEKPVI SVYPPIRHHL MDKQGVYVTS PLVSNFTMHS DLGKIIQSLL
DEFWKNPPVL APTSTAFPYL YSNSGGMPPY ASQRFPFLPS YPPQEANRTI TPLSVADTVS
SSTTSYTTAK PAAPSFGILS SLPLPIPTTD TSAPISQNGF GYKMPDVPDA FPELSELSVS
QLTDMNEQEE LLLEQFLTLP QLKQIITDKD DLVKSIEELA RKNLLLEPSL EAKRQIVLDK
YELLTQMKSA FEKKMQRQHE LSESCSASTL QARLKVAAHE AEEESDNIAE DFLEGKTEID
DFLSSFMEKR TICHCRRAKE EKLQQVIAMH SHFHAPL
//
