ID G5B8S6_HETGA Unreviewed; 263 AA.
AC G5B8S6;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 46.
DE SubName: Full=Transcription factor Spi-B {ECO:0000313|EMBL:EHB05687.1};
GN ORFNames=GW7_15323 {ECO:0000313|EMBL:EHB05687.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB05687.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB05687.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU004019}.
CC -!- SIMILARITY: Belongs to the ETS family. {ECO:0000256|ARBA:ARBA00005562,
CC ECO:0000256|RuleBase:RU004019}.
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DR EMBL; JH169009; EHB05687.1; -; Genomic_DNA.
DR RefSeq; XP_004866880.1; XM_004866823.1.
DR AlphaFoldDB; G5B8S6; -.
DR STRING; 10181.G5B8S6; -.
DR GeneID; 101699321; -.
DR KEGG; hgl:101699321; -.
DR CTD; 6689; -.
DR eggNOG; KOG3805; Eukaryota.
DR InParanoid; G5B8S6; -.
DR OMA; CKHPSYP; -.
DR OrthoDB; 3980839at2759; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000418; Ets_dom.
DR InterPro; IPR046328; ETS_fam.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11849; ETS; 1.
DR PANTHER; PTHR11849:SF174; TRANSCRIPTION FACTOR SPI-B; 1.
DR Pfam; PF00178; Ets; 1.
DR PRINTS; PR00454; ETSDOMAIN.
DR SMART; SM00413; ETS; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR PROSITE; PS50061; ETS_DOMAIN_3; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004019};
KW Nucleus {ECO:0000256|RuleBase:RU004019};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813}.
FT DOMAIN 170..253
FT /note="ETS"
FT /evidence="ECO:0000259|PROSITE:PS50061"
FT REGION 142..163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 263 AA; 28697 MW; 83D99D7E3ABCEA26 CRC64;
MLALEAAQLD GPHFSFLYPD GVFYDLDSCK HPGYPDSEGA PDSLWGWTEA PPVPAAPYEA
FDPAAATFGP PQAAQLCYGP SAYSPAGTLE PAPSLETPGP GLPAYPTEDF AGQTLGPLAY
APYPSPGLSE EEELLLLDSP ALEVSDSESD ETLGSSPEGR GSEAGARKKL RLYQFLLGLL
TRGDMRECVW WVEPGAGVFQ FSSKHKELLA RRWGQQKGNR KRMTYQKLAR ALRNYAKTGE
IRKVKRKLTY QFDSALLPGV RRA
//
