ID G5B8U5_HETGA Unreviewed; 488 AA.
AC G5B8U5;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Ankyrin repeat and SOCS box protein 3 {ECO:0000313|EMBL:EHB05706.1};
GN ORFNames=GW7_15240 {ECO:0000313|EMBL:EHB05706.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB05706.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB05706.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SIMILARITY: Belongs to the ankyrin SOCS box (ASB) family.
CC {ECO:0000256|ARBA:ARBA00005949}.
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DR EMBL; JH169012; EHB05706.1; -; Genomic_DNA.
DR AlphaFoldDB; G5B8U5; -.
DR STRING; 10181.G5B8U5; -.
DR eggNOG; KOG0504; Eukaryota.
DR InParanoid; G5B8U5; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd03722; SOCS_ASB3; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR Gene3D; 1.10.750.20; SOCS box; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037329; ASB3_SOCS.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR24166:SF52; ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 65; 1.
DR PANTHER; PTHR24166; ROLLING PEBBLES, ISOFORM B; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF07525; SOCS_box; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 9.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 3.
DR PROSITE; PS50225; SOCS; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 78..110
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 142..174
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 175..207
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 422..469
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
SQ SEQUENCE 488 AA; 54799 MW; 7ADC202254A4C554 CRC64;
MDFTEAYSDT CSTVGLAVRE DNVKILRKLL KKGRSIDVAD NRGWMPIHEA AYHNSIECLQ
ILIHTDSSEN YIKTKTFEGF CALHFAASQG HWKIAQILLE AGADPNATTL EETTPLFLGD
ENVEIIKLLL KKGADKECQD DFGITPLFLA AQYGKLESLS ILISSGAKVN CQALDKATPL
FIAAQEGHTK CVKLLLSNGA DPNLYCNEDS WQLPIHAAAQ MGHTKILDLL IPLTNRVCET
GPDKVSPVYS AVFGGREKCL ELLLQNGYSP DAQMCLVFGF SSPMCMAFQK DCEFLGIVNI
LLKYGARLNE LHLAYCLKYE KFSVFRYFLK KGCPLGPWNH ISEFINHAIK AQTKYKEWLP
HLLLAGFDPL TLLCSSWIDS VSEDTLIFTL EFTNWKRLPP AVEKMLSVRA LNSSWVLQQW
LASVPSLSHL CRLEIRASLK TEHLKSDSFI RQLPLPRSLH NYLLYEETLR MNEVPELAVH
DGEISEAT
//
