ID G5B9Q2_HETGA Unreviewed; 395 AA.
AC G5B9Q2;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE SubName: Full=DNA-directed RNA polymerase III subunit RPC4 {ECO:0000313|EMBL:EHB06013.1};
GN Name=POLR3D {ECO:0000313|EMBL:JAN99086.1};
GN ORFNames=GW7_20728 {ECO:0000313|EMBL:EHB06013.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB06013.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB06013.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
RN [2] {ECO:0000313|EMBL:JAN99086.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Skin {ECO:0000313|EMBL:JAN99086.1};
RA Bens M., Sahm A., Jahn N., Morhart M., Holtze S., Hildebrandt T.B.,
RA Platzer M., Szafranski K.;
RT "FRAMA: From RNA-seq data to annotated mRNA assemblies.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; JH169129; EHB06013.1; -; Genomic_DNA.
DR EMBL; GEBF01004546; JAN99086.1; -; Transcribed_RNA.
DR AlphaFoldDB; G5B9Q2; -.
DR STRING; 10181.G5B9Q2; -.
DR eggNOG; KOG3122; Eukaryota.
DR InParanoid; G5B9Q2; -.
DR OMA; QAENTCT; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR Bgee; ENSHGLG00000015415; Expressed in pituitary gland and 10 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005666; C:RNA polymerase III complex; IEA:Ensembl.
DR GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0045089; P:positive regulation of innate immune response; IEA:Ensembl.
DR GO; GO:0032728; P:positive regulation of interferon-beta production; IEA:Ensembl.
DR GO; GO:0006383; P:transcription by RNA polymerase III; IEA:InterPro.
DR InterPro; IPR007811; RPC4.
DR PANTHER; PTHR13408; DNA-DIRECTED RNA POLYMERASE III; 1.
DR PANTHER; PTHR13408:SF0; DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC4; 1.
DR Pfam; PF05132; RNA_pol_Rpc4; 1.
PE 4: Predicted;
KW DNA-directed RNA polymerase {ECO:0000313|EMBL:EHB06013.1};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Transcription {ECO:0000256|ARBA:ARBA00023163}.
FT REGION 1..116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 62..100
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 395 AA; 43842 MW; 6C14258B5268DE2A CRC64;
MSEGNAAGGP STPGGPRPIL SGSRGLIGRR PAPSLPPGRL PSMRSRDLTL GGVKKKTFTP
NIISRKIKEE PKEEATVKKE KRERDRDRQR EGHGRGRGRP EVIQSHSIFE QGPAEMMKKK
GNWDKTVDMS DIGPSHIINI KKEKRETDEE TKQILRMLEK DDFIDDPGLR NDTRNMPVQL
PLAHSGWLFK DESEEPDVKP WLAGAKEEDM EINTPAVKVK EEPGDEAEMK APPRLARKTP
GLPKDVSVAE LLRELSLTKD EELLFLQLPD TLPGQPPTQD IKPVKTEVQG DDGQMVVIKQ
EKDREARLAE NSCTLADLTE GQVGKLLIRK SGKVQLLLGK VTLDVTMGST CSFLQELVSV
GLGDSRTGDM TVLGHVKHKL VCSPDFESLL DHKHR
//
