ID G5BA96_HETGA Unreviewed; 1032 AA.
AC G5BA96;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Toll-like receptor 7 {ECO:0000313|EMBL:EHB06207.1};
GN ORFNames=GW7_05279 {ECO:0000313|EMBL:EHB06207.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB06207.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB06207.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, phagosome
CC {ECO:0000256|ARBA:ARBA00004262}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004115}. Lysosome
CC {ECO:0000256|ARBA:ARBA00004371}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR EMBL; JH169221; EHB06207.1; -; Genomic_DNA.
DR AlphaFoldDB; G5BA96; -.
DR STRING; 10181.G5BA96; -.
DR eggNOG; KOG4641; Eukaryota.
DR InParanoid; G5BA96; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR GO; GO:0045335; C:phagocytic vesicle; IEA:UniProtKB-SubCell.
DR GO; GO:0002218; P:activation of innate immune response; IEA:UniProt.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0001819; P:positive regulation of cytokine production; IEA:UniProt.
DR GO; GO:0051171; P:regulation of nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0080090; P:regulation of primary metabolic process; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR041283; LRR_12.
DR InterPro; IPR026906; LRR_5.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR47410:SF2; TOLL-LIKE RECEPTOR 7; 1.
DR PANTHER; PTHR47410; TOLL-LIKE RECEPTOR 7-RELATED; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF18837; LRR_12; 1.
DR Pfam; PF13306; LRR_5; 1.
DR Pfam; PF13855; LRR_8; 3.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00364; LRR_BAC; 5.
DR SMART; SM00365; LRR_SD22; 8.
DR SMART; SM00369; LRR_TYP; 13.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 5.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:EHB06207.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 823..848
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 872..1016
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 1032 AA; 120117 MW; 23C71D5CD2C6C480 CRC64;
MMLISRLLGA RWFPKTLPCD ISLDPSKTHV IVDCTDKHLT EIPEGIPTNA TNLTLTINHI
PSISPDSFHN LDHLIEVDFR CNCVPIRMGA KKNMCVRRLQ IKPRSFSRLT YLKSLYLDGN
QLLEIPQDLP PSLQLLSLEA NNIFVIMKEN LTELVNIEML FLGQNCYYRN PCNVSYSIEK
NAFLNLRNLK VLSLKDNNIT AVPTLLPSNL TELYLYNNII TNIQEDDFNN LNQLEILDLS
GNCPRCYNVP FPCIPCENNS PLQIHVNAFD ALTELQVLRL HSNSLQHVPV RWFKNMKNLR
ELDLSQNYLA KEIGDAKFLH LLPNLIQLDL SFNYELQVYH AFINLSHSFS SLKNLKILRI
KGYVFKELRY LNLSPLHDLH NLEVLDLGTN FIKIANLSIF KQFQKLKFID LSMNKISPSE
DSSEIGFCSN TRTSVESNGP QVLETLHYFR YDKYARSCRF KNMETPFLTF NNDCNMYGQT
LDLSRNNIFF VKPSDFQHLS FLKCLNLSGN TIGQTLNGSE FQHLEQLKYL DFSNNRLDLL
HSTAFEELHN LEVLDLSMNS HYFQSEGITH MLNFTKNLKF LKKLMMNDND ISTSTSRTME
SKSLKILEFR GNHLDILWRD GDNRYLKFFK NLLNLEELDI SRNSLSFLPP GVFDGMPPNL
KTLSLAKNGL QTFNWRKLSF LKNLEILDLS HNQLTTLPER LSNCSRSLKK LILMKNQIRH
LTKYFLKDAF QLRYLDLSSN KIQVIQKTSF PQNVLNNLEM LLLHRNRFLC NCDAVWFVWW
VNHTDVTIPY LATEVTCVGP GAHKGQSVVS LDLYTCELNL INLILFSVSI SVALFLMVVM
TASHLYFWDM WYIYHFFKAK LRGYQRLRSA ECCYDAFIVY DTKDPAVTEW VLDELVARLE
DPREKHFNLC LEERDWLPGQ PVLENLSQSI QLSKKTVFVM TEKYAKTENF KIAFYLSHQR
LMDEKVDVII LIFLEKPFTK SKFLQLRKRL CGSSVLEWPT NPQAHPYFWQ CLKNALAMDN
HVVYSQMFKE TV
//
