ID G5BAX9_HETGA Unreviewed; 568 AA.
AC G5BAX9;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE RecName: Full=Endonuclease/exonuclease/phosphatase family domain-containing protein 1 {ECO:0000256|ARBA:ARBA00015260};
GN ORFNames=GW7_00169 {ECO:0000313|EMBL:EHB06440.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB06440.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB06440.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
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DR EMBL; JH169321; EHB06440.1; -; Genomic_DNA.
DR AlphaFoldDB; G5BAX9; -.
DR STRING; 10181.G5BAX9; -.
DR eggNOG; KOG1857; Eukaryota.
DR InParanoid; G5BAX9; -.
DR OMA; HLVPANT; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR CDD; cd10283; MnuA_DNase1-like; 1.
DR Gene3D; 1.10.150.280; AF1531-like domain; 1.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR Gene3D; 1.10.150.320; Photosystem II 12 kDa extrinsic protein; 1.
DR InterPro; IPR004509; Competence_ComEA_HhH.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR InterPro; IPR010994; RuvA_2-like.
DR NCBIfam; TIGR00426; competence protein ComEA helix-hairpin-helix repeat region; 1.
DR PANTHER; PTHR21180; ENDONUCLEASE/EXONUCLEASE/PHOSPHATASE FAMILY DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR21180:SF32; ENDONUCLEASE/EXONUCLEASE/PHOSPHATASE FAMILY DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF03372; Exo_endo_phos; 1.
DR Pfam; PF12836; HHH_3; 2.
DR SMART; SM00278; HhH1; 3.
DR SUPFAM; SSF56219; DNase I-like; 1.
DR SUPFAM; SSF47781; RuvA domain 2-like; 2.
PE 4: Predicted;
KW Endonuclease {ECO:0000313|EMBL:EHB06440.1};
KW Exonuclease {ECO:0000313|EMBL:EHB06440.1};
KW Hydrolase {ECO:0000313|EMBL:EHB06440.1};
KW Nuclease {ECO:0000313|EMBL:EHB06440.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813}.
FT DOMAIN 48..67
FT /note="Helix-hairpin-helix DNA-binding motif class 1"
FT /evidence="ECO:0000259|SMART:SM00278"
FT DOMAIN 78..97
FT /note="Helix-hairpin-helix DNA-binding motif class 1"
FT /evidence="ECO:0000259|SMART:SM00278"
FT DOMAIN 145..164
FT /note="Helix-hairpin-helix DNA-binding motif class 1"
FT /evidence="ECO:0000259|SMART:SM00278"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 200..227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 543..568
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 568 AA; 62571 MW; 0D327395F768047D CRC64;
MGSTLGCHRS IPRDPSDLSH SRKFSAACNF SNILVNQERL NINTATEEEL MTLPGVTRVV
AHSIVEYREY IGGFKKVEDL ALVSGVGATK LEQVKFEICV SSKGSSAQHS PSSLRRDLLA
EQQPHHLVTS VPLTPRVNIN TATPAQLMSV RGLTEKLALS IVDYRREHGP FRSVEDLVRM
DGINAAFLDR IRHQVFAERS RPPSTQTNGG LTFTARPHPS PTSLSLQSED LDLPPGGPTQ
IISTRPSVEA FGGTRDGQLV LRLATWNLQG CSMEKANNPG VREVVCMTLL ENSIKLLAVQ
DILDKEALEK FCAELNQPVL PNIRKWRGPR GCWRSLVTEK PSSQFQKSAG YSGFLWDTAA
GVEVRDAAWQ ESPSNGHGRP PAPSSHLARF KVGSNEVTLV NLHLAALSLP ATENPSKNPS
DSHRLASLAQ TLQGTLKGEK DVIILGDFGQ GPDSSDYDIL RREKFHHLIP AHIFTNISTK
NPQGSKSLDN IWISKSLKKV FTGHWAVVRE GLTNPWIPDN WSWGGVASEH CPVLAEFYIE
KDWGKKDGPQ DSGRVTLEHS EANTKQER
//