ID G5BAY3_HETGA Unreviewed; 846 AA.
AC G5BAY3;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE SubName: Full=Acyloxyacyl hydrolase {ECO:0000313|EMBL:EHB06444.1};
GN ORFNames=GW7_00173 {ECO:0000313|EMBL:EHB06444.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB06444.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB06444.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
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DR EMBL; JH169321; EHB06444.1; -; Genomic_DNA.
DR AlphaFoldDB; G5BAY3; -.
DR eggNOG; ENOG502QVQW; Eukaryota.
DR InParanoid; G5BAY3; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0050528; F:acyloxyacyl hydrolase activity; IEA:InterPro.
DR Gene3D; 1.10.225.10; Saposin-like; 1.
DR Gene3D; 3.40.50.1110; SGNH hydrolase; 1.
DR InterPro; IPR039676; AOAH.
DR InterPro; IPR048593; AOAH_Saposin_N.
DR InterPro; IPR001087; GDSL.
DR InterPro; IPR011001; Saposin-like.
DR InterPro; IPR008139; SaposinB_dom.
DR InterPro; IPR036514; SGNH_hydro_sf.
DR PANTHER; PTHR15010; ACYLOXYACYL HYDROLASE; 1.
DR PANTHER; PTHR15010:SF0; ACYLOXYACYL HYDROLASE; 1.
DR Pfam; PF00657; Lipase_GDSL; 1.
DR Pfam; PF20825; Saposin; 1.
DR SMART; SM00741; SapB; 1.
DR SUPFAM; SSF47862; Saposin; 1.
DR SUPFAM; SSF52266; SGNH hydrolase; 1.
DR PROSITE; PS50015; SAP_B; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000313|EMBL:EHB06444.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..846
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003474161"
FT DOMAIN 61..142
FT /note="Saposin B-type"
FT /evidence="ECO:0000259|PROSITE:PS50015"
FT REGION 370..397
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 846 AA; 95822 MW; C65AC53AC6A3FE43 CRC64;
MRSVITLLKG YIFCQVVTQV DSSEMKSPCR ILKVAPVFLL LLLRFLASPA SDDQFNMGHS
NGHRCLGCVL VMSVITQLAQ VHNSTVEASM ERLCSYLPGK LFLKTTCYLL VHLFGSDIIK
LLDADMNADM VCHTLEFCKQ DSGRPQCHLY PLPKEAWKLR QEKAKHTVKK SENMKYLKGG
SDICSLPFLA KICQKIKLSI QTSMPFKDVD SDKYSVFPTL RGYHWRGRDC NDSDKTVYPG
RRPDNWDAHR DSNCNGIWGI DPKDGIPYEK KFCEGSQPRG IILLGDSAGA HFHIPPEWLI
ASQMSLVSNL GSNHSGCAAL CFRFPLLSFN VVPAPNRCRF ASSAKSAMKG KSTAISALGK
GKLRVSLPHL SSLSPTAARN PEDGSGTERL KTKGKPHVRH LQDNEGVANQ WYWEVFDLKA
KQIGFVSGSP EVLTTSFLQK PELSVHKQKR SSKPSITTAQ MAEEKNSFSD LPTALTDELD
WPQLSSATGF LNSTSGIEEK SIYLRLRKRN RCNHRDYQNI SRNGASSRNL RKFIESLSRN
QMLDYPAIVI YAMIGNDVCN GRADPVQAMT TPEQLYSNIM QTLKHLDSHL PKGSHMVLYG
LPNGTFLWEN LHDRYHPLGQ LNKDVTYAQV FSFLSCLQVN PCHGWMSSNK TLRTLTSERA
QQLSNTLKTI AAREKFTNFD LFYMDFAFEE ITEEWQKRGG QPWQLIEPVD GFHPNEFGDC
AEQFRETRCL YNPLRACWQP GKKGIWCQRD LVSQELVGWI WHGGICLQNW DQTQKSTPLT
EEWQKRGGQP WQLIEPVDGF HPNEVASLLL TDIFWKKMQR QWPQVLGKEN PFNSQIDQVF
GDQGGH
//
