ID G5BB68_HETGA Unreviewed; 1897 AA.
AC G5BB68;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 54.
DE SubName: Full=Bromodomain adjacent to zinc finger domain protein 2A {ECO:0000313|EMBL:EHB06529.1};
GN ORFNames=GW7_15747 {ECO:0000313|EMBL:EHB06529.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB06529.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB06529.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SIMILARITY: Belongs to the WAL family. {ECO:0000256|ARBA:ARBA00007444}.
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DR EMBL; JH169329; EHB06529.1; -; Genomic_DNA.
DR STRING; 10181.G5BB68; -.
DR eggNOG; KOG1245; Eukaryota.
DR InParanoid; G5BB68; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd05503; Bromo_BAZ2A_B_like; 1.
DR CDD; cd01397; HAT_MBD; 1.
DR CDD; cd15629; PHD_BAZ2A; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR017956; AT_hook_DNA-bd_motif.
DR InterPro; IPR037374; BAZ2A/B_Bromo.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR018501; DDT_dom.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR InterPro; IPR001739; Methyl_CpG_DNA-bd.
DR InterPro; IPR028940; PHD_BAZ2A.
DR InterPro; IPR028942; WHIM1_dom.
DR InterPro; IPR028941; WHIM2_dom.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45915:SF5; BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 2A; 1.
DR PANTHER; PTHR45915; TRANSCRIPTION INTERMEDIARY FACTOR; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR Pfam; PF02791; DDT; 1.
DR Pfam; PF01429; MBD; 1.
DR Pfam; PF00628; PHD; 1.
DR Pfam; PF15612; WHIM1; 1.
DR Pfam; PF15613; WSD; 1.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00384; AT_hook; 4.
DR SMART; SM00297; BROMO; 1.
DR SMART; SM00571; DDT; 1.
DR SMART; SM00391; MBD; 1.
DR SMART; SM00249; PHD; 1.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR SUPFAM; SSF54171; DNA-binding domain; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS00633; BROMODOMAIN_1; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
DR PROSITE; PS50827; DDT; 1.
DR PROSITE; PS50982; MBD; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 3: Inferred from homology;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035}; Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 529..600
FT /note="MBD"
FT /evidence="ECO:0000259|PROSITE:PS50982"
FT DOMAIN 831..896
FT /note="DDT"
FT /evidence="ECO:0000259|PROSITE:PS50827"
FT DOMAIN 1670..1720
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 1802..1872
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT REGION 1..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 359..413
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 630..777
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1009..1044
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1154..1257
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1279..1406
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1753..1783
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..56
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 373..392
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 636..695
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 719..777
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1009..1033
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1156..1172
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1184..1213
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1223..1238
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1340..1376
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1897 AA; 211086 MW; 27012BC7F27E7E4A CRC64;
MEANDHFNFT GLPPAPAASG LKPSPSSGEG LYTNGSPMNF PQQGKSLNGD VNVNGLSTVS
HTTTSGILNS APHSSSTSHL HHPNVAYDCL WNYSQYPSAN PGSNLKDPPL LSQFSGGQYP
LNGILGGSRQ PSPSHNTNLR AGSQEFWGNG TQSPMGLNFD SQELYDSFPD QNFEVMPNGP
PGFFTSPQTS PMLGSSIQTF APSQEVGSVI HPDEAAEKEL TSVVAENGTG LVGSLELEEE
QPELKMCGYN GSVPSVESLH QEVSVLVPDP TVSCLDDPSH LPDQLEDTPI LNEDSLEPFD
SLAPEPVSGG LYGIDDTELM GAEDKLPLED SPVISALDCP SLNNATPFSL LADDSQTSAS
IFSSPASPPV LGESVLQDNS FDLNNGSDVE QEEMETQGSD FPPPLAQPHP DQSSTIQIQL
HPVASPAVSP TASPEISAPE VSLSVSPAAS PRLCPAACPV LSPVSSAVSS EVALTAPVGS
PKASSVTSPA SAFLANKDVS SFHEATGDLE EITGDVTTSG NADVLRRRIA TPEEVRLPLQ
HGWRREVRIK KGSHRWQGET WYYGPCGKRM KQFPEVIKYL SRNVVHSVRR EHFSFSPRMP
VGDFFEERDT PEGLQWVQLS AEEIPSRIQA ITGKRGRPRN NEKAKTKEVP KVKRGRGRPP
KVKIPELLNK TDNRLPKKLE AQETLNEEDK AKMSKSKKKM RQKIQRGECQ TPIQGQAKTK
RKPETKSLKQ KDPKKKLKAE KEKIKTKQEK LKEKMKKEKK EKVKMKEKDE MAKAKPTCKA
DKTLATQRRL EERQRQQMIL EEMKKPTEDM CLADHQPLPE FTRIPGLTLP SRAFSDCLTI
VEFLHSFGKV LGFDPTKDVP SLGVLQEGLL CQGDSLGKVQ DLLVRLLKAA LYDPGLPSYC
QSLKILGEKV CEIPLTRDNV SEILRCFLMA YGVEPTLCDS LRTQPFQAQP PQQKAAVLAF
LVHELNGSTL IINEIDKTLE SMSSYRKNKW IVEGRLRRLK TTLAKRTGRP EVEMEGPEEG
LGRRRSSRIM EETSGMEEEE EEEEEETVAA LHGRRGRRDG EVDAVASSIP ELERQIEKLS
KRQLFFRKKL LHSSQMLRAV SLGQDRYRRR YWVLPYLAGI FVEGAEGSLV PEDMIKQETD
SLKTHSGLTP ALFSVKKELS GSSTSASSPA RTRGRPRKTK PGSMQPRNLK SSLKGQDSEQ
PQDQLQPKAQ PEPQPQASTQ PHPQFEPHPE SQLQPQPQLH HGFLEPEGSP LSLGQSQHDL
SQSAFLSWLT QTQSHGSLLS SSVLTPDSSP GKLDPAPSQP LEEPEEAESG PGPPVSWFNF
LAEVPCNAAP TPPPAVSEDQ STPSPQLPAS SKPMNRPSAA NPCSPAQFSS TLLTGVTPKR
RAADSREKPQ SPTGLGQPKR RGRPPSKFFK QMEQRYLTQL TAQPVPPEMR SGWWWIRDPE
MLDAMLKALH PRGIREKALH KHLNKHRNFL QEVCSRPSAD PIFEPSQLPP FEEGIMSWSP
KEKTYETDLA VLQWVEDLEQ RVILSDLQIR GWTCPSPDSI REDLAYCEHL PDSQEDITWR
GRSREGLAPQ RKSTNPLDLA VMRLAALEQN VERRYLREPL WSAHEVVLEK ALLSTPNGAP
EGTTKEISYE ITPRVRVWRQ TLERCRSAAQ VCLCMGQLER SIAWEKSVNK VTCLVCRKGD
NDEFLLLCDG CDRGCHIYCH RPKMEAVPEG DWFCAVCLAQ VEEEFTQKPG FPKRGQKRKS
AYSLNFPEAD GRRRRVLSRG RESPSSVPRY SEEGLPPSKR RRLPMRNHSD LTFCEIILME
MESHDAAWPF LEPVNPRLVS GYRRIIKNPM DFSTMRERLL RGGYTSSEEF AADALLVFDN
CQTFNEDDSE VGKAGHIMRQ FFESRWEEFY QGKQANL
//
