ID G5BEF2_HETGA Unreviewed; 2603 AA.
AC G5BEF2;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 50.
DE SubName: Full=Teneurin-4 {ECO:0000313|EMBL:EHB07663.1};
DE Flags: Fragment;
GN ORFNames=GW7_00216 {ECO:0000313|EMBL:EHB07663.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB07663.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB07663.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004162};
CC Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the tenascin family. Teneurin subfamily.
CC {ECO:0000256|ARBA:ARBA00009385}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; JH169811; EHB07663.1; -; Genomic_DNA.
DR STRING; 10181.G5BEF2; -.
DR eggNOG; KOG4659; Eukaryota.
DR InParanoid; G5BEF2; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 1.
DR Gene3D; 2.10.25.10; Laminin; 7.
DR Gene3D; 2.180.10.10; RHS repeat-associated core; 2.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 2.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR008969; CarboxyPept-like_regulatory.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR013111; EGF_extracell.
DR InterPro; IPR022385; Rhs_assc_core.
DR InterPro; IPR031325; RHS_repeat.
DR InterPro; IPR009471; Ten_N.
DR InterPro; IPR028916; Tox-GHH_dom.
DR InterPro; IPR006530; YD.
DR NCBIfam; TIGR03696; Rhs_assc_core; 1.
DR NCBIfam; TIGR01643; YD_repeat_2x; 2.
DR PANTHER; PTHR11219; TENEURIN AND N-ACETYLGLUCOSAMINE-1-PHOSPHODIESTER ALPHA-N-ACETYLGLUCOSAMINIDASE; 1.
DR PANTHER; PTHR11219:SF9; TENEURIN-4; 1.
DR Pfam; PF07974; EGF_2; 1.
DR Pfam; PF05593; RHS_repeat; 1.
DR Pfam; PF06484; Ten_N; 1.
DR Pfam; PF15636; Tox-GHH; 1.
DR SMART; SM00181; EGF; 8.
DR SUPFAM; SSF63829; Calcium-dependent phosphotriesterase; 1.
DR SUPFAM; SSF49464; Carboxypeptidase regulatory domain-like; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF101898; NHL repeat; 1.
DR PROSITE; PS00022; EGF_1; 5.
DR PROSITE; PS01186; EGF_2; 4.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS51361; TENEURIN_N; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 177..202
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..177
FT /note="Teneurin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51361"
FT DOMAIN 462..494
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 632..667
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 1..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 236..259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..53
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 484..493
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 636..646
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 657..666
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT NON_TER 2603
FT /evidence="ECO:0000313|EMBL:EHB07663.1"
SQ SEQUENCE 2603 AA; 289644 MW; 3573AF3204346FFF CRC64;
DHPGGLQNHP RLRTPPPPLS HAHTPNQHHG ASVNSLNRGN FTPRSNPSPA PTDHSLSGEP
PVGSAQEPTH AQDNWLLNSN IPLETRNLSK QPFLGTLQDN LIEMDILSAS RHDGAYSDGH
FLFKPGGTSP LFCTTSPGYP LTSSTVYSPP PRPLPRSTFA RPTFNLKKPS KYCNWKCAAL
SAIIISATLI ILLAYFVAMH LFGLNWHLQP MEGQMYEITE DTASSWPVPT DVSLYPSGGT
GLETPDRKGK GATEGKSSSF FPEDSFIDSG EIDVGRRASQ KIPPGTFWRA QVFIDHPVHL
KFNVSLGKAA LVGIYGRKGF PPSHTQFDFV ELLDGRRLLT QEARSLEGPQ RQSRGGVPPA
SHETGFIQYL DSGIWHLAFY NDGKESEVVS FLTTAIESVD NCPSNCYGNG DCISGTCHCF
LGFLGPDCGR ASCPVLCSGN GQYMKGRCLC HSGWKGAECD VPTNQCIDVT CSNHGTCIMG
TCICNPGYKG ESCEEVDCMD PTCSGRGVCV RGECHCSVGW GGTNCETPRA TCLDQCSGHG
TFLPDTGLCS CDPSWTGHDC SIEICAADCG GHGVCVGGTC RCEDGWMGAA CDQRACHPRC
AEHGTCRDGK CECSVGWNGE HCTIAHYLDR VVKEGCPGLC NGNGKCTLDL NGWQCVCHLG
WRGAGCDTSM ETACGDSKDN DGDGLADCMD PDCCLQPLCH VNSLCLGSPD PLDIIQETKS
PVSQQNLHSF YDRIKFLVGR DSTHIIPGEN PFDGGHACVI RGQVMTSDGT PLVGVNISFV
NNPLFGYTVS RQDGSFDLVT NGGISIILRF ERAPFITQEH TLWLPWDRFF VMETIVMRHE
ENEIPSCDLS NFARPNPVVS PSPLTSFASS CAEKGPIVPE IQALQEEIAI SGCKIRLSYL
SSRTPGYKSV LRISLTHPTI PFNLMKVHLM VAVEGRLFRK WFAAAPELSY YFIWDKTDVY
NQKVFGLSEA FVSVGYEYES CPDLILWEKR TAVLQGYEID ASKLGGWSLD KHHALNIQSG
ILHKGNGENQ FVSQQPPVIG SIMGNGRRRS ISCPSCNGLA DGNKLLAPVA LTCGSDGSLY
VGDFNYIRRI FPSGNVTNIL ELRNKDFRHS HSPAHKYYLT TDPMSGAVFL SDTNSRRVFK
IKSTMVVKDL VKNSEVLAGT GDQCLPFDDT RCGDGGKATE ATLTNPRGIT VDKFGLIYFV
DGTMIRRVDQ NGIISTLLGS NDLTSARPLS CDSVMDISQV RLEWPTDLAI NPMDNSLYVL
DNNVVLQISE NHQVRIVAGR PMHCQVPGID XKVAIHATLE SATALAVSHN GVLYIAETDE
KKINRIRQVT TSGEISLVAG APSGCDCKND ANCDCFSGDD GYAKDAKLNT PSSLAVCADG
DLYVADLGNI RIRFIRKNKP FLNTQNMYEL SSPIDQELYL FDTSGKHLYT QSLPTGDYLY
NFTYTGDGDV TLITDNNGNM VNVRRDSTGM PLWLVVPDGQ IYWVTMGTNS ALRSVTTQGH
ELAIMTYHGN SGLLATKSNE NGWTTFYEYD SFGRLTNVTF PTGQVSSFRS DTDSSVHVQV
ETSSKDDVTI TTNLSASGAF YTLLQDQVRN SYYIGADGSL RLLLANGMEV ALQTEPHLLA
GTVNPTVGKR NVTLPIDNGL NLVEWRQRKE QARGQVTVFG RRLRVHNRNL LSLDFDRVTR
TEKIYDDHRK FTLRILYDQA GRPSLWSPSS RLNGVNVTYS PGGHIAGIQR GIMSERMEYD
QAGRITSRIF ADGKTWTYTY LEKASSMVLL LHSQRQYIFE FDKNDHLSSV TMPNVARQTL
ETIRSVGYYR NIYQPPEGNA SVIQDFTEDG HLLHTFYLGT GRRVIYKYGK LSKLAEMLYD
TTKVSFTYDE TAGMLKTVNL QNEGFTCTIR YRQIGPLIDR QIFRFTEEGM VNARFDYNYD
NSFRVTSMQA VINETPLPID LYRYDDVSGK TEQFGKFGVI YYDINQIITT AVMTHTKHFD
TYGRMKEVQY EIFRSLMYWM TVQYDNMGRV VKKELKVGPY ANTTRYSYEY DADGQLQMVS
INDKPLWRYS YDLNGNLHLL SPGNSARLTP LRYDIRDRIT RLGDVQYKMD EDGFLRQRGG
DVFEYNSAGL LIKAYNRAGG WSVRYHYDGL GRRVSSKNSY SHHLQFFYAD LTNPTKVTHL
YNHSSSEITS LYYDLQGHLF AMELSSGDEF YIACDNIGTP LAVFSGTGLM IKQILYTAYG
EIYMDTNPNF QIIIGYHGGL YDPLTKLIHM GRRDYDVLAG RWTSPDHELW KHLSSNNIMP
FNLYMFKNNN PISNSQDIKC FMTDVNSWLL TFGFQLHNVI PGYPKPDMDA MEPSYELLHT
QMKTQEWDNS KSILGVQCEV QKQLKAFVTL ERFDQLYGST VTSCQQAPET RKFASSGSVF
GKGVKFSLKD GRVTTDIISM ANEDGRRVAA ILNNAHYLEN LHFTINGIDT HYFVKPGPSE
GDLAILGLSG GQRTLENGVN VTVSQINTML NGRTRRYTDI QLQYRALCLN TRYGTTLDEE
KARVLELARQ RAVRQAWAQE QQRLQEGEEG LRAWTEGEKQ QVLNTGQVQG YDGFFVISVE
QYPELSDSAN NIHFMRQSEM GRR
//
