ID G5BEW0_HETGA Unreviewed; 513 AA.
AC G5BEW0;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Patatin-like phospholipase domain-containing protein 1 {ECO:0000313|EMBL:EHB07821.1};
GN ORFNames=GW7_00634 {ECO:0000313|EMBL:EHB07821.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB07821.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB07821.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
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DR EMBL; JH169897; EHB07821.1; -; Genomic_DNA.
DR AlphaFoldDB; G5BEW0; -.
DR STRING; 10181.G5BEW0; -.
DR eggNOG; KOG3773; Eukaryota.
DR InParanoid; G5BEW0; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 2.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR033562; PLPL.
DR InterPro; IPR002641; PNPLA_dom.
DR PANTHER; PTHR12406; CALCIUM-INDEPENDENT PHOSPHOLIPASE A2 IPLA2 -RELATED; 1.
DR PANTHER; PTHR12406:SF23; OMEGA-HYDROXYCERAMIDE TRANSACYLASE; 1.
DR Pfam; PF01734; Patatin; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR PROSITE; PS51635; PNPLA; 1.
PE 4: Predicted;
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813}.
FT DOMAIN 16..190
FT /note="PNPLA"
FT /evidence="ECO:0000259|PROSITE:PS51635"
FT REGION 296..513
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 345..362
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 391..411
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 412..429
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 447..488
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 513 AA; 55854 MW; 7CD887AD399F30C5 CRC64;
MEEQVFKGDP DTPHSISFSG SGFLSYYQAG AVDALRDLAP RMLDTAHRFA GTSAGAVIAA
LVICGIEMEE YLRVLNLGLA EVKKYFLGPF APSCRMVQMM RRFLYTALPE DAYKVATGKL
HVGLTRFEDG ESVVVSDFTS KEELIEARIP GALYCSCFVP VYCGFIPPTY RGVRYIDGGF
TSMQPCPFWT DSITISTFSG QQDICPRDCP AIFNDFRMFN YSFQFSLENI TRMTHALFPP
DLVILQDYYY RGYEDAVAYL RRLNAVYINS PSRSVMFPRV EVYSQIELAL GPKCPQSPWP
RPEEPAPLHA HWAPRGAGKG SHPSAPPPVQ MLEPMSEGPL GSPVSSLKPS PPLLPGSPLP
RSPGDLAPGH FIPSSTPGSS PPVVPPGRSL VSPRQQVQPS GVPFNTSTSP RPSAVPAPPT
SPRGCPSASP ARPPVELLGP EQPRALLASS NPKSATAPTN VKETVSKSNV MESPTADSNW
ANKVFKRNKQ KTSSSRKGFP RHPPAKTPNS KVQ
//
