ID G5BIR0_HETGA Unreviewed; 908 AA.
AC G5BIR0;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE SubName: Full=Integrin alpha-4 {ECO:0000313|EMBL:EHB09171.1};
GN ORFNames=GW7_14235 {ECO:0000313|EMBL:EHB09171.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB09171.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB09171.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR EMBL; JH170535; EHB09171.1; -; Genomic_DNA.
DR AlphaFoldDB; G5BIR0; -.
DR STRING; 10181.G5BIR0; -.
DR InParanoid; G5BIR0; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 2.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF78; INTEGRIN ALPHA-4; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 5.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR PROSITE; PS51470; FG_GAP; 4.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT REPEAT 48..113
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 239..298
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 302..359
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 363..425
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 410..567
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 569..636
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT DOMAIN 692..862
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
SQ SEQUENCE 908 AA; 100442 MW; D6808DA117353EDE CRC64;
MLTGTLPFPS VYTPAAGQAC PLATDWWLGR GTKKGTGTVE VPGAHPYNVD AESALLFRGA
PGTLFGYSRV LHSHGPDRWL VVGAPTATWL ANASVLSPGA IYKCRIGKNP SRTCEQLQLG
SPTGEPCGKT CLEERDNQWL GVTLSRQPGE NGSIVTCGHR WKNIFYVRHE NKLPTGVCYG
MPSDLRTELS KRMAPCYQGY SVGAGHFRSP HTTEVVGGAP QHEQIGKAYV FSIDAKELNI
LYEMKGKKLG SYFGASICAV DLNADGFSDL LVGAPMHSTV REEGRVFVFI NSGVGAVMNE
METALIGSDK YAARFGESIV NLGDIDNDGF EDVAIGAPQE DELRGAIYIY NGRVDGISSA
FSQRIGGLQI SESLSMFGQS ISGQIDADNN GYIDVAVGAF RSESAVLLRT RPVVIVEASL
SHPESVNRTK FDCVENGAPS VCMDLKLCFS YKGKEVPGYI VLFYNMSLDV NRKAESPSRF
YFSSNGTSDV ITGSIQVSSR RANCRTHQAF MRKDVRDILT PIQIEAAYHL GHHVISKRST
EEFPPLQPIL QQKKEKDMIK KVINFARFCA HENCSADLQV SAKIGFFKPY ENKTYLAVGS
TKTLMLNVSL FNAGDDAYET TLYIRLPTGL YFIKILDLTD VSFLLDVSSL RRAEEDLNIM
VLASCANEGE MDKLQDNKVI VAIPLRYEVM LAVHGFVNPA SFVYGSSEDN EPETCMTEKM
NFTFHVINMG ISMAPNVSVE IMIPNSFLPR TDKLFNILDV QTTTGQCKFE NYPRECATEQ
QRYAVETLKG ILTFLSKTDR RVLYCMKADP YCLSFLCNFG KMESGKEASV HIQLEGRPSI
LEMDDTSALK FEIRATAFPE PHPRVIELNK DENAAHAGFF KRQYKSILQE ENRDSWSYVN
SKSNDNDD
//
