ID G5BIX7_HETGA Unreviewed; 687 AA.
AC G5BIX7;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=Nucleolar GTP-binding protein 2 {ECO:0000256|RuleBase:RU364023};
GN ORFNames=GW7_13012 {ECO:0000313|EMBL:EHB09238.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB09238.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB09238.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- FUNCTION: GTPase that associates with pre-60S ribosomal subunits in the
CC nucleolus and is required for their nuclear export and maturation.
CC {ECO:0000256|RuleBase:RU364023}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|RuleBase:RU364023}.
CC -!- SIMILARITY: Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2
CC subfamily. {ECO:0000256|RuleBase:RU364023}.
CC -!- SIMILARITY: Belongs to the calcium channel beta subunit family.
CC {ECO:0000256|ARBA:ARBA00010836}.
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DR EMBL; JH170542; EHB09238.1; -; Genomic_DNA.
DR STRING; 10181.G5BIX7; -.
DR InParanoid; G5BIX7; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR CDD; cd12043; SH3_CACNB4; 1.
DR Gene3D; 3.30.1310.30; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR046937; CAB1-4_N_A-dom.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR006073; GTP-bd.
DR InterPro; IPR012971; NOG2_N_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR000584; VDCC_L_bsu.
DR PANTHER; PTHR11824; VOLTAGE-DEPENDENT CALCIUM CHANNEL BETA SUBUNIT; 1.
DR PANTHER; PTHR11824:SF7; VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-4; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF01926; MMR_HSR1; 1.
DR Pfam; PF08153; NGP1NT; 1.
DR Pfam; PF12052; VGCC_beta4Aa_N; 1.
DR PRINTS; PR01626; LCACHANNELB.
DR SMART; SM00072; GuKc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|RuleBase:RU364023};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU364023};
KW Nucleus {ECO:0000256|RuleBase:RU364023};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 94..163
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 573..687
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 573..622
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 623..668
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 687 AA; 77905 MW; 63703AC52ACD4FD0 CRC64;
MFLLLVVRPS DSDVSLEEDR EAIRQEREQQ AAIQLERAKV TFFPSFGSTL ACSQVLSAAL
ALPHISLDSH FLIVLLKLQV VRLSGAVTLR ESKPVAFAVK TNVSYCGALD EDVPVPSTAI
SFDAKDFLHI KEKYNNDWWI GRLVKEGCEI GFIPSPLRLE NIRIXKFQEE MDTVLKDPYK
VVMKQSKLPM SLLRDQIQPH NSKLHILDTE SFETTFGPKS QRKRPNLFVS DMQSLMEKAE
ISTESYDQGK DRNLVTKHTG VRNETQEEMY KKGQSKRIWE YPTLAFHASL TNPFGKGAFI
QLLQQFGKLH TDKKQISIGF IGYPNVGKSS VINTLCSKKV CNVARIAGNR VEILLQVLEK
WYQGHFEQPP HQQTEHIPPY DVVPSMRPVV LVGPSLKGYE VTDMMQKALF DFLKHRFDGR
ISITRVTADI SLAKRSVLNN PSKRAIIERS NTRSSLAEVQ SEIERIFELA RSLQLVVLDA
DTINHPAQLI KTSLAPIIVH VKVSSPKVLQ RLIKSRGKSQ SKHLNVQLVA ADKLAQCPPE
MFDVILDENQ LEDACEHLGE YLEAYWRATH TTSSTPMTPL LGRNLGSTAL SPYPTAISGL
QSQRMRHSNH STENSPIERR SLMTSDENYH NERARKSRNR LSSSSQHSRD HYPLVEEDYP
DSYQDTYKPH RNRGSPGGCS HDSRHRL
//
