ID G5BJC0_HETGA Unreviewed; 542 AA.
AC G5BJC0;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=DNA polymerase sigma {ECO:0000313|EMBL:EHB09381.1};
GN ORFNames=GW7_18015 {ECO:0000313|EMBL:EHB09381.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB09381.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB09381.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
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DR EMBL; JH170566; EHB09381.1; -; Genomic_DNA.
DR RefSeq; XP_004845215.1; XM_004845158.2.
DR RefSeq; XP_004845220.1; XM_004845163.2.
DR AlphaFoldDB; G5BJC0; -.
DR STRING; 10181.G5BJC0; -.
DR Ensembl; ENSHGLT00100022835; ENSHGLP00100022600; ENSHGLG00100016621.
DR GeneID; 101716019; -.
DR KEGG; hgl:101716019; -.
DR CTD; 11044; -.
DR eggNOG; KOG1906; Eukaryota.
DR InParanoid; G5BJC0; -.
DR OMA; KWGSRVH; -.
DR OrthoDB; 21395at2759; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR Bgee; ENSHGLG00000005593; Expressed in pituitary gland and 10 other cell types or tissues.
DR GO; GO:1990817; F:poly(A) RNA polymerase activity; IEA:InterPro.
DR GO; GO:0016070; P:RNA metabolic process; IEA:UniProt.
DR CDD; cd05402; NT_PAP_TUTase; 1.
DR Gene3D; 1.10.1410.10; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR002058; PAP_assoc.
DR InterPro; IPR002934; Polymerase_NTP_transf_dom.
DR InterPro; IPR045862; Trf4-like.
DR PANTHER; PTHR23092; POLY(A) RNA POLYMERASE; 1.
DR PANTHER; PTHR23092:SF24; TERMINAL NUCLEOTIDYLTRANSFERASE 4A; 1.
DR Pfam; PF01909; NTP_transf_2; 1.
DR Pfam; PF03828; PAP_assoc; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81631; PAP/OAS1 substrate-binding domain; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000006813}.
FT DOMAIN 16..121
FT /note="Polymerase nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF01909"
FT DOMAIN 178..237
FT /note="PAP-associated"
FT /evidence="ECO:0000259|Pfam:PF03828"
FT REGION 324..377
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 488..542
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 347..377
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 542 AA; 59902 MW; BC3175DFE2A9FFD7 CRC64;
MSPRPEEAAM RREVVQRIET VVKDLWPTAD VQIFGSFSTG LYLPTSDIDL VVFGEWERPP
LQLLEQALRK HSVAEPCSIK VLDKATVPII KLTDQETEVK VDISFNMETG VRAAEFIKNY
MKEYSLLPYL ILVLKQFLLQ RDLNEVFTGG ISSYSLILMA ISFLQLHPRI DARRADENLG
MLLVEFFELY GRNFNYLKTG IRIKEGGAYI AKEEIMKAMT SGYRPSMLCI EDPLLPGNDV
GRSSYGAMQV KQVFDYAYIV LSHAVSPLAR SYPNRDSEST LGRIIKVTQE VIDYRRWIKE
KWGSRVHPLP DLDNRIKMKE RLSMCNGEQT PGREPRSPYS PRLALSLCSP QPLSSGSSAS
SVSSLSGSDV DSDTPPCTTP SVYQFSLQAP AALVGSLPAA LPMPSAKPQA TPSRTLIMTP
NNQTRFAMPA PTLGVAPVPC RQAGVERTAS SKAGHHMPAP AVPAAPPNPL CSPHLYHKQH
NGMKLSMKGS HGHAQGGGYG SVGSGGVRPP MGNRGHHQYN RTGWRRKKHT HTRDSLPVSL
SR
//
