ID G5BJY4_HETGA Unreviewed; 1211 AA.
AC G5BJY4;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Dyslexia-associated protein KIAA0319 {ECO:0008006|Google:ProtNLM};
GN ORFNames=GW7_06351 {ECO:0000313|EMBL:EHB09595.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB09595.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB09595.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; JH170673; EHB09595.1; -; Genomic_DNA.
DR STRING; 10181.G5BJY4; -.
DR eggNOG; ENOG502QR8M; Eukaryota.
DR InParanoid; G5BJY4; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR CDD; cd00146; PKD; 4.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR029865; KIAA0319-like.
DR InterPro; IPR013980; MANSC_dom.
DR InterPro; IPR011106; MANSC_N.
DR InterPro; IPR022409; PKD/Chitinase_dom.
DR InterPro; IPR000601; PKD_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR PANTHER; PTHR46182:SF1; DYSLEXIA-ASSOCIATED PROTEIN KIAA0319; 1.
DR PANTHER; PTHR46182; FI19480P1; 1.
DR Pfam; PF18911; PKD_4; 1.
DR SMART; SM00765; MANEC; 1.
DR SMART; SM00089; PKD; 5.
DR SUPFAM; SSF49299; PKD domain; 4.
DR PROSITE; PS50986; MANSC; 1.
DR PROSITE; PS50093; PKD; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..1211
FT /note="Dyslexia-associated protein KIAA0319"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003474574"
FT TRANSMEM 1095..1120
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 12..98
FT /note="MANSC"
FT /evidence="ECO:0000259|PROSITE:PS50986"
FT DOMAIN 672..757
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT REGION 180..391
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 413..432
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1173..1211
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 193..217
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 351..377
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1175..1190
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1193..1211
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1211 AA; 129449 MW; E11D20C4651133B4 CRC64;
MALTGKLLSL LLLVTAAGCT GQPCSEGRTY SNAIISPDLE TIRIMPVPQT FSVGDCTAAC
CDLPSCDLAW WFEGHCHLVS CPQRESCTPK RTGPIHSYLT FVLRPPARPE XXXXXXXXXX
XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX PAERPEQLLD YGEMMLSKGV
PSGAWGEPPE DLLKDLPFLD RGGGLEEPTD YVEDGYRDLE PGLLPTNLPS PLGDAQDAGW
GAGVANASLG DGPSALVSAD HPAFTGVGPA FTEDGPSASV SVGDHPGSPR DSPKASTSPA
DGPVASGSTE EKPQDAELGP STPQHPTPSK AARLATPIPS SLPSLGPSSP SPEQGPDKDN
PSQPQAPSGN SPGAQVLIPS HSPPPASLEF TPVTVEKSPI LIVNTWSTEL STPTLPTGTV
PSGASPSEHP ISPKTAQLLS VSAGDNLFLT LPQDSVELKA LVVPVPPADT TYSYEWSLVS
HPVDYQGELK LGNTEALNLS HLSAGVYAFK VTVSSDNAFG EGFVNVTVKP VTISVMHGSG
SGQQSKRLES RLITGADTGI KFPFPGLTQK SGRDNLPPVA VVSPQEQELT LPLTLALLDG
SQSTDDTKIV SYHWEEVSGP FLEEKTSTDC PILHLSHLVP GNYTFLTVTD SDGATNSTTA
TLIVNSAVDY PPVASAGSNQ TITLPQNTIT LNGNRSSDDH QIVLYEWSLG PGSESKEGAG
TPYLHVSAMQ EGEYTFQLIV TDSSGQQSTA EVTVIVQPED NRPPVAVAGP DKELVFPVNS
ATLDGSRSSD DHGIVLYRWE HVRGPSAVEM ANGNAAVATV TGLQVGTHHF RLTVKDQQGL
SSTSTLTVAV KEENNSPPRA QAGGRHVLVL PNNSITLDGS RSTDDQGIAS YLWIRDGQSP
AAGDVIGGSD HSVALQLTDL VEGVYTFHLR VTDPHGASDT DTATVEVRPD PSKGGLVELI
LQVGAGQLME QQKDALVRRL ATLLGTLDSD VRVQKIQPHS DVSTAVVFYV QSGPPFKVLQ
AAQVARSLHR RLSKEKADFL LFKVLRIDTA GCLLTCSGHG HCDPITKRCV CSALWMENPV
QRYLWDAESN CEWSILYVAM LASALTVLMG GITWLCICCC KRRKRTKIRK KTKYTILDNM
DEQERMELRP KYGLKHCSTE HNSSLMVSES EFDSDQDTIF SRERMEREDT QGSMNGPVGN
GTSFSYCSED R
//
