ID G5BK21_HETGA Unreviewed; 788 AA.
AC G5BK21;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Ras GTPase-activating protein SynGAP {ECO:0000313|EMBL:EHB09632.1};
GN ORFNames=GW7_09861 {ECO:0000313|EMBL:EHB09632.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB09632.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB09632.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
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DR EMBL; JH170678; EHB09632.1; -; Genomic_DNA.
DR AlphaFoldDB; G5BK21; -.
DR STRING; 10181.G5BK21; -.
DR eggNOG; KOG3508; Eukaryota.
DR InParanoid; G5BK21; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR CDD; cd05136; RasGAP_DAB2IP; 1.
DR CDD; cd22265; UDM1_RNF168; 1.
DR InterPro; IPR021887; DAB2P_C.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR PANTHER; PTHR10194:SF25; RAS_RAP GTPASE-ACTIVATING PROTEIN SYNGAP; 1.
DR Pfam; PF12004; DAB2P_C; 2.
DR Pfam; PF00616; RasGAP; 2.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813}.
FT DOMAIN 30..222
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 493..546
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 742..788
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 592..658
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 529..546
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 788 AA; 87982 MW; 03073B8491A39EF3 CRC64;
MELYKEFAEY VTSHYRMLCA VLEPALSVKG KEEVASALVH ILQSTGKAKD FLSDMAMSEV
DRFMEREHLI FRENTLATKA IEEYMRLIGQ KYLKDAIGEF IRALYESEEN CEVDPIKCTA
SSLAEHQANL RMCCELALCK VVNSHCVFPR ELKEVFASWR LRCAERGRED IADRLISASL
FLRFLCPAIM SPSLFGLMQE YPDEQTSRTL TLIAKVIQNL ANFSKFTSKE DFLGFMNEFL
ELEWGSMQQF LYEISNLDTL TNSSSFEGYI DLGRELSTLH ALLWEVLPQL SKEALLKLGP
LPRLLNDIST ALRNPNIQRQ PSRQSERARA QPVVLRGPSA EMQGYMMRDL NSSIDLQSFM
ARGLNSSMDM ARIPSPTKEK PPPPPGAGKD LFYVSRPPLA RSSPAYCTSS SDITEPEQKM
LSVNKSVSML DLQGDGPGGR LNSSSVSNLA AVGDLLHSSQ ASLTAALGLR PAPPGRLSQG
SGSSITAAGM RLSQMGGPEQ GSRPGTFLSG GSSPPPHTCP FPPLLSPRRA LSQHSQTPST
LNPTMPASER TVAWVSNMPH LSADIESAHI EREEYKLKEY SKSMDESRLD RVKEYEEEIH
SLKERLHMSN RKLEEYERRL LSQEEQTSKI LMQYQARLEQ SEKRLRQQQV EKDSQIKSII
GRLMLVEEEL RRDHPAMAEP LPEPKKRLLD AQVEITMSFI FSVSHPHPSH CPPCTRRTGQ
PSPITVVSAC SVLLCPLAAP CSPPPHQERQ LPPLGPTNPG VTLAPPWNGL APPVQITENG
EFRNTADH
//
