ID G5BKD0_HETGA Unreviewed; 1128 AA.
AC G5BKD0;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=Guanylate cyclase {ECO:0000256|ARBA:ARBA00012202, ECO:0000256|RuleBase:RU003431};
DE EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202, ECO:0000256|RuleBase:RU003431};
GN ORFNames=GW7_14637 {ECO:0000313|EMBL:EHB09731.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB09731.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB09731.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2;
CC Evidence={ECO:0000256|RuleBase:RU003431};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
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DR EMBL; JH170748; EHB09731.1; -; Genomic_DNA.
DR AlphaFoldDB; G5BKD0; -.
DR STRING; 10181.G5BKD0; -.
DR eggNOG; KOG1023; Eukaryota.
DR InParanoid; G5BKD0; -.
DR OMA; LYQGNHV; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 6.10.250.780; -; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR001170; ANPR/GUC.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR PANTHER; PTHR11920:SF500; GUANYLATE CYCLASE 2G; 1.
DR PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PRINTS; PR00255; NATPEPTIDER.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 3: Inferred from homology;
KW cGMP biosynthesis {ECO:0000256|ARBA:ARBA00023293,
KW ECO:0000256|RuleBase:RU003431};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 492..513
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 659..683
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 545..854
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 929..1059
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
SQ SEQUENCE 1128 AA; 125666 MW; 2D135A4A79203699 CRC64;
MPFMVLRIGP KAPLDSGLCW GTECHVGHTT LVLMLFATML VTWLEAAKLT VGFHAPWNIS
HPVSAQRLGA GLQIAMDKVN AKPVVGLGNF SWEFTYTDSA CSTKGSLAVF INQVQKEQIS
ALFGPACPEA AEVTGLLASE WNIPMFDFVG QMAILENHFL YDTCVTLVPP KQEIGDVLQK
SLQYLGWKHI GMFGSCYGAS SWDELDKLWR VVEEELQSQF TITASMRCTS HDPALLQEAL
RNVSALARVI ILICSSEDAK RILLAAENLG LDTREFVFII LQQLEVGADY HLVALDSFRK
ELLTNQKVTQ FPTVYESVFL ISPSSYREGP GQDDFRKQVY QRLRGAPFHS PIASEEQVSP
YAAYLHDAFL LYARTVGEMI KAGRDFRDGR QLLSTLRANP TPLQGITGSV FVDSQGERHM
DYSVYALQKS GNGTFFLPFL HYDSYNKVIR SLRNFSNITW PRDFLPGNRL RPGCGFPNEL
CQVEPTFPGG TVVILTVMLL VTVLGVATVA LAVRVQQGKR QSRNKDTWWQ INYEDITILT
QNKPSQRSTL MSRGDHSDVS SGMSSVDLYS FVKSPQREEL LFAPVGLYQG NHVAIHYAGD
QANAWVRKPT MLQEVRLMCE LRHENIVSFF GVCTEPPNIC LVTQYCKKGS LKQVSLEQAA
LPILILCCFG SLVVMFGLVQ LLVLKHCVLV WLKGMLFLHR SPLGSHGNLQ PSNCLVDACM
QVKLSGFGLW ELKYGQTHRA QNEKTTDHTE LYWTAPELLR LPQVPWRGTP KGDVYSFAVL
MRDLIHHQDH GPFEDLDAAP DEIIKQIREP TAAGPLRPSL SEERGSAEIL VMVRTCWDES
PERRPTFSSI KKILREASPG GQVNILDSMM SKLEVYASHL EEVVDERTSQ LMAEKRKVEK
LLSTMLPSFI GEQLIAGKSV EPEHFESVTI FFSDIVGFTK LCSLSSPLQV VKLLNDLYSL
FDHIVQTYDV YKVETIGDAY MVASGLPIRN GTQHVDQVAT MALSLLGATI HFQIGHMPEE
KLQLRIGLHT GPVVAGVVGV TMPRYCLFGD TVNMASRMES SGLPLRIHVS QSTAGALLAM
GGYHLQKRGT IPVKGKGEQT TFWLKGKEGF TIPLPEFPEE EVGDPEIV
//
