ID G5BKR5_HETGA Unreviewed; 421 AA.
AC G5BKR5;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE RecName: Full=Thyroxine-binding globulin {ECO:0000256|ARBA:ARBA00039512};
DE AltName: Full=Serpin A7 {ECO:0000256|ARBA:ARBA00043177};
DE AltName: Full=T4-binding globulin {ECO:0000256|ARBA:ARBA00042967};
GN ORFNames=GW7_09460 {ECO:0000313|EMBL:EHB09876.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB09876.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB09876.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- FUNCTION: Major thyroid hormone transport protein in serum.
CC {ECO:0000256|ARBA:ARBA00037352}.
CC -!- SIMILARITY: Belongs to the serpin family.
CC {ECO:0000256|ARBA:ARBA00009500, ECO:0000256|RuleBase:RU000411}.
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DR EMBL; JH170774; EHB09876.1; -; Genomic_DNA.
DR AlphaFoldDB; G5BKR5; -.
DR STRING; 10181.G5BKR5; -.
DR MEROPS; I04.955; -.
DR eggNOG; KOG2392; Eukaryota.
DR InParanoid; G5BKR5; -.
DR OMA; CFKAQWA; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR Gene3D; 2.30.39.10; Alpha-1-antitrypsin, domain 1; 1.
DR Gene3D; 3.30.497.10; Antithrombin, subunit I, domain 2; 1.
DR Gene3D; 2.10.310.10; Serpins superfamily; 1.
DR InterPro; IPR023795; Serpin_CS.
DR InterPro; IPR023796; Serpin_dom.
DR InterPro; IPR000215; Serpin_fam.
DR InterPro; IPR036186; Serpin_sf.
DR InterPro; IPR042178; Serpin_sf_1.
DR InterPro; IPR042185; Serpin_sf_2.
DR PANTHER; PTHR11461; SERINE PROTEASE INHIBITOR, SERPIN; 1.
DR PANTHER; PTHR11461:SF375; THYROXINE-BINDING GLOBULIN; 1.
DR Pfam; PF00079; Serpin; 1.
DR SMART; SM00093; SERPIN; 1.
DR SUPFAM; SSF56574; Serpins; 1.
DR PROSITE; PS00284; SERPIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..421
FT /note="Thyroxine-binding globulin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003474431"
FT DOMAIN 54..418
FT /note="Serpin"
FT /evidence="ECO:0000259|SMART:SM00093"
SQ SEQUENCE 421 AA; 47317 MW; 4557B3B62B223722 CRC64;
MSVFLYLITF LLGLHATTKG APPSSSEGKV PTCYLPQQND TFYKMSSINA DFAFNLYRKF
AVEIPDQNIF FSPVSISAAL AMLSFGAGSS TQTQILEALG FNFTDTSVAE IQQGFQYLIC
SLNFPKKELE LQIGNALFIG KKLKPLPKFL DGVKTLYETD VFSTDFSNVS AAEQAINCQV
EKQTKGKIVN LIHDLKLNAI MVLVNYIHFK AQWANPFQPS KTEDSSNFLV DKIITVKVPM
MHQVEQYHYL VDMELNCTVL QMDYNKNALA LFVLPKKGQM EWVEASMSSK TLKKWNRLLQ
KGWVNLFVPK FSISATHDLR IMLLKMGIED AFADKADFSG LTEDNGLKLS YAAHKALLHI
GEKGSDDVND VTVSEVISMD QSEITLLHPI IRFDRTFLLM ILEKNTRSIL FLGKVVNPTE
V
//
