ID G5BMD7_HETGA Unreviewed; 577 AA.
AC G5BMD7;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=La-related protein 7 {ECO:0000256|ARBA:ARBA00015867};
DE AltName: Full=La ribonucleoprotein domain family member 7 {ECO:0000256|ARBA:ARBA00029640};
GN ORFNames=GW7_01308 {ECO:0000313|EMBL:EHB10448.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB10448.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB10448.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm
CC {ECO:0000256|ARBA:ARBA00004642}.
CC -!- SIMILARITY: Belongs to the LARP7 family.
CC {ECO:0000256|ARBA:ARBA00008680}.
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DR EMBL; JH171001; EHB10448.1; -; Genomic_DNA.
DR RefSeq; XP_004867653.1; XM_004867596.2.
DR RefSeq; XP_004867654.1; XM_004867597.2.
DR RefSeq; XP_004867655.1; XM_004867598.1.
DR AlphaFoldDB; G5BMD7; -.
DR STRING; 10181.G5BMD7; -.
DR Ensembl; ENSHGLT00100000423; ENSHGLP00100000392; ENSHGLG00100000332.
DR GeneID; 101726505; -.
DR KEGG; hgl:101726505; -.
DR CTD; 51574; -.
DR eggNOG; KOG0118; Eukaryota.
DR InParanoid; G5BMD7; -.
DR OMA; ANASHDW; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR Bgee; ENSHGLG00000002716; Expressed in testis and 10 other cell types or tissues.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:1990904; C:ribonucleoprotein complex; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR CDD; cd08032; LARP_7; 1.
DR CDD; cd12290; RRM1_LARP7; 1.
DR CDD; cd12542; RRM2_LARP7; 1.
DR Gene3D; 3.30.70.330; -; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR045180; La_dom_prot.
DR InterPro; IPR006630; La_HTH.
DR InterPro; IPR014886; La_xRRM.
DR InterPro; IPR034946; LARP7_La.
DR InterPro; IPR034887; LARP7_RRM1.
DR InterPro; IPR034910; LARP7_RRM2.
DR InterPro; IPR002344; Lupus_La.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR22792:SF140; LA-RELATED PROTEIN 7; 1.
DR PANTHER; PTHR22792; LUPUS LA PROTEIN-RELATED; 1.
DR Pfam; PF05383; La; 1.
DR Pfam; PF00076; RRM_1; 1.
DR Pfam; PF08777; RRM_3; 1.
DR PRINTS; PR00302; LUPUSLA.
DR SMART; SM00715; LA; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 2.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50961; HTH_LA; 1.
DR PROSITE; PS50102; RRM; 1.
DR PROSITE; PS51939; XRRM; 1.
PE 3: Inferred from homology;
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00332}; Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 24..118
FT /note="HTH La-type RNA-binding"
FT /evidence="ECO:0000259|PROSITE:PS50961"
FT DOMAIN 121..184
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 445..558
FT /note="XRRM"
FT /evidence="ECO:0000259|PROSITE:PS51939"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 184..364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..26
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 234..260
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 276..297
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 314..349
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 577 AA; 65801 MW; 349D984CCD702EA0 CRC64;
MEAEGGNQAM EESSEKKEVE KKKRSRVKQV LADIAKQVDF WFGDANLHKD RFLREQIEKS
RDGYVDISLL VSFNKMKKLT TDGKLIARAL KSSAIVELDL EGTRIRRKKP LGERPKDEDE
RTVYVELLPK NVNHSWIEKV FGKCGNVVYI SIPHYKSTGD PKGFAFVEFE TKEQAAKAIE
FLNNPPEEAP RKPGIFPKTV KNKPIPVLRV AEEKKKKKKK KGRMKKEDNV QEKGLSMDTS
SVSICKVKAS RTTSEGSETE SAEPQKQHTK KKKKRDRAEV SSLPEGRPEK RKRSSSADAA
ESLAPKSKIK KIAPKNVKKE ASEVSKDNRD LEFSTEEEKD TGDIQGSLLK TKRKHKKKHK
ERHKMGEEVI PLRVLSKNEW MDLKKEYLAL QKASMASLKK TISQIKSESE METDSGVPSK
IAVKKEEANG PECRPQEKVN PPGPQFLSGV IVKITSPEPL PGRKQLRDTL AAISEVVYVD
LLEGDTECHA RFKTPEAAQG IMNRHTEIKK KHSWELEVLT GDHEQRYWQK ILVDRQAKLN
QPREKKRGTE KLITKAEKIR LEKTQQASKH IRFSEYD
//
