ID G5BMF9_HETGA Unreviewed; 1059 AA.
AC G5BMF9;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 48.
DE RecName: Full=Integrin beta {ECO:0000256|RuleBase:RU000633};
GN ORFNames=GW7_13901 {ECO:0000313|EMBL:EHB10470.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB10470.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB10470.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU000633}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU000633}.
CC Membrane raft {ECO:0000256|ARBA:ARBA00035630}; Single-pass type I
CC membrane protein {ECO:0000256|ARBA:ARBA00035630}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the integrin beta chain family.
CC {ECO:0000256|ARBA:ARBA00007449, ECO:0000256|RuleBase:RU000633}.
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DR EMBL; JH171006; EHB10470.1; -; Genomic_DNA.
DR AlphaFoldDB; G5BMF9; -.
DR STRING; 10181.G5BMF9; -.
DR eggNOG; KOG1226; Eukaryota.
DR InParanoid; G5BMF9; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0006909; P:phagocytosis; IEA:UniProtKB-KW.
DR Gene3D; 6.20.50.10; -; 1.
DR Gene3D; 1.20.5.100; Cytochrome c1, transmembrane anchor, C-terminal; 1.
DR Gene3D; 2.10.25.10; Laminin; 4.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 2.
DR InterPro; IPR015439; Integrin_b-2_sf.
DR InterPro; IPR033760; Integrin_beta_N.
DR InterPro; IPR015812; Integrin_bsu.
DR InterPro; IPR014836; Integrin_bsu_cyt_dom.
DR InterPro; IPR012896; Integrin_bsu_tail.
DR InterPro; IPR036349; Integrin_bsu_tail_dom_sf.
DR InterPro; IPR002369; Integrin_bsu_VWA.
DR InterPro; IPR032695; Integrin_dom_sf.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10082; INTEGRIN BETA SUBUNIT; 1.
DR PANTHER; PTHR10082:SF15; INTEGRIN BETA-2; 1.
DR Pfam; PF08725; Integrin_b_cyt; 1.
DR Pfam; PF07965; Integrin_B_tail; 1.
DR Pfam; PF00362; Integrin_beta; 2.
DR Pfam; PF17205; PSI_integrin; 1.
DR PRINTS; PR01186; INTEGRINB.
DR SMART; SM00187; INB; 1.
DR SMART; SM01241; Integrin_b_cyt; 1.
DR SMART; SM01242; Integrin_B_tail; 1.
DR SMART; SM00423; PSI; 2.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF69687; Integrin beta tail domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF53300; vWA-like; 2.
DR PROSITE; PS00243; INTEGRIN_BETA; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU000633};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU000633};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phagocytosis {ECO:0000256|ARBA:ARBA00022907};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Pyrrolidone carboxylic acid {ECO:0000256|ARBA:ARBA00023283};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000633};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 991..1013
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 182..232
FT /note="PSI"
FT /evidence="ECO:0000259|SMART:SM00423"
FT DOMAIN 190..737
FT /note="Integrin beta subunit VWA"
FT /evidence="ECO:0000259|SMART:SM00187"
FT DOMAIN 911..953
FT /note="PSI"
FT /evidence="ECO:0000259|SMART:SM00423"
FT DOMAIN 912..990
FT /note="Integrin beta subunit tail"
FT /evidence="ECO:0000259|SMART:SM01242"
FT DOMAIN 1014..1059
FT /note="Integrin beta subunit cytoplasmic"
FT /evidence="ECO:0000259|SMART:SM01241"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 93..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 27..41
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1059 AA; 114848 MW; 2ABF8DC9F5C49703 CRC64;
MCSDRNSRAQ DPPERPAPPL EQLLSGLGTG LQANEGLSSN CSGSCQCVRP EDSSEQAQPA
PKCMAVCLGL AVPEEPAARA RADLSRATCS HLVAGPGGQG PGSFEVRRDH SAAGKEQVNT
PPAQPDPAQA RGASGPAPCG GKDRGPGQDR LPGTALSQDM LAPCLPPALL GLLCLGSALS
QECTKYKVST CRDCIQSGPG CAWCQNLNFT GPGEPDSARC DTREQLLKRG CVPDDIVDPR
SLAAPQEDHA GGQKQLFPQK VTLYLRPGQA ATFNVTFRRA KGYPVDLYYL MDLSYSMLDD
LINVKKLGGD LLQALNEITE SGRIGFGSFV DKTVLPFVNT HPEKLRNPCP SKEEECQPPF
AFRHVLKLTN NSNQFRTEVG KQLISGNLDD PAGGLEGRAG QAATFNVTFR RAKGYPVDLY
YLMDLSYSML DDLINVKKLG GDLLQALNEI TESGRIGFGS FVDKTVLPFV NTHPEKLRNP
CPSKEEECQP PFAFRHVLKL TNNSNQFRTE VGKQLISGNL DAPEGGLDAM MQVAACQEEI
GWRNVTRLLV FATDDGFHFA GDGKLGAILT PNDGHCHLED NMYKRSNEFD YPSVGQLVHK
LTESNIQPIF AVTQKMVTTY EKLAEIIPKA AVGELSDDSS NVVQLIKNAY NKLSSRVVLG
HSTLPDTLKV TYDSFCSNGV THTDQPKGDC DGVQISVPVT FQVKVTATEC IQAQSLDIRA
LGFTDTVTVR VLPQCECRCR DQRQNRGLCG GKGSMECGVC RCEAGYIGKS CECQTQGRSS
QELEGSSRKD NSSTVCSGLG DCVCGQCVCH TSDIPNKVIY GRYCECDNMN CERYDGQVCG
GPRRGLCDCG RCLCEPGFEG SACQCKSSTE GCLNARRVVC SGRGRCRCNT CECDMGYQPP
LCEECAVCPS PCAQHISCAE CLKFVSGPFE KNCSTACGHL KPLTSAATGK SCRERDSQGC
WMTYTLRQRD GRDSYDIHVE DTRECVEGPN IAAIVGGTVA GIVLIGVLLL VVWKALTHLS
DLREYRRFEK ERSKSQWNND NPLFKSATTT VMNPKFADS
//
