ID G5BMJ4_HETGA Unreviewed; 708 AA.
AC G5BMJ4;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=F-box/WD repeat-containing protein 7 {ECO:0000313|EMBL:EHB10505.1, ECO:0000313|EMBL:JAO00812.1};
GN Name=FBXW7 {ECO:0000313|EMBL:JAO00812.1};
GN ORFNames=GW7_21587 {ECO:0000313|EMBL:EHB10505.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB10505.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB10505.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
RN [2] {ECO:0000313|EMBL:JAO00812.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Skin {ECO:0000313|EMBL:JAO00812.1};
RA Bens M., Sahm A., Jahn N., Morhart M., Holtze S., Hildebrandt T.B.,
RA Platzer M., Szafranski K.;
RT "FRAMA: From RNA-seq data to annotated mRNA assemblies.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; JH171101; EHB10505.1; -; Genomic_DNA.
DR EMBL; GEBF01002821; JAO00812.1; -; Transcribed_RNA.
DR RefSeq; XP_004869243.1; XM_004869186.2.
DR RefSeq; XP_004869244.1; XM_004869187.2.
DR RefSeq; XP_012922680.1; XM_013067226.1.
DR AlphaFoldDB; G5BMJ4; -.
DR STRING; 10181.G5BMJ4; -.
DR GeneID; 101717987; -.
DR CTD; 55294; -.
DR eggNOG; KOG0274; Eukaryota.
DR InParanoid; G5BMJ4; -.
DR OrthoDB; 587035at2759; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR Bgee; ENSHGLG00000003387; Expressed in heart and 10 other cell types or tissues.
DR GO; GO:0043170; P:macromolecule metabolic process; IEA:UniProt.
DR GO; GO:0006807; P:nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0044238; P:primary metabolic process; IEA:UniProt.
DR CDD; cd22133; F-box_FBXW7; 1.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 1.20.1280.50; -; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19849:SF1; F-BOX_WD REPEAT-CONTAINING PROTEIN 7; 1.
DR PANTHER; PTHR19849; PHOSPHOLIPASE A-2-ACTIVATING PROTEIN; 1.
DR Pfam; PF12937; F-box-like; 1.
DR Pfam; PF00400; WD40; 7.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00256; FBOX; 1.
DR SMART; SM00320; WD40; 8.
DR SUPFAM; SSF81383; F-box domain; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50181; FBOX; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 5.
DR PROSITE; PS50082; WD_REPEATS_2; 7.
DR PROSITE; PS50294; WD_REPEATS_REGION; 6.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 279..325
FT /note="F-box"
FT /evidence="ECO:0000259|PROSITE:PS50181"
FT REPEAT 392..417
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 418..457
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 458..497
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 498..537
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 538..577
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 578..617
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 621..660
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..31
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 44..59
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 67..92
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 93..131
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 708 AA; 79708 MW; 90815EED6F7F9276 CRC64;
MNQELLSVGS KRRRTGGSLR GNPSSSQVDE EQMNRVVEEE QQQQPLRQQE EEHTARNGEV
VGAEPRSGAQ NDSQQGQVEE NNNRFISVDE DSSGNQEEQE EDEEHAGEQD EEDEEEEEMD
QESDDFDQSD DSSREDEHIH SNSVTNSSST VDLPIHQLSS PFYTKTTKMK RKLDHGSEVR
SFSLGKKPCK VSEYTSTTGL VPCSATPTTF GDLRAANGQG QQRRRITSVQ PPTGLQEWLK
MFQSWSGPEK LLALDELIDS CEPTQVKHMM QVIEPQFQRD FISLLPKELA LYVLSFLEPK
DLLQAAQTCR YWRILAEDNL LWREKCKEEG IDEPLHIKRR KVIKPGFIHS PWKSAYIRQH
RIDTNWRRGE LKSPKVLKGH DDHVITCLQF CGNRIVSGSD DNTLKVWSAV TGKCLRTLVG
HTGGVWSSQM RDNIIISGST DRTLKVWNAE TGECIHTLYG HTSTVRCMHL HEKRVVSGSR
DATLRVWDIE SGQCLHVLMG HVAAVRCVQY DGRRVVSGAY DFMVKVWDPE TETCLHTLQG
HTNRVYSLQF DGIHVVSGSL DTSIRVWDVE TGNCIHTLTG HQSLTSGMEL KDNILVSGNA
DSTVKIWDIK TGQCLQTLQG PNKHQSAVTC LQFNKNFVIT SSDDGTVKLW DLKTGEFIRN
LVTLESGGSG GVVWRIRASN TKLVCAVGSR NGTEETKLLV LDFDVDMK
//
