ID G5BN18_HETGA Unreviewed; 347 AA.
AC G5BN18;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Interferon-inducible GTPase 1 {ECO:0000313|EMBL:EHB10679.1};
DE Flags: Fragment;
GN ORFNames=GW7_17084 {ECO:0000313|EMBL:EHB10679.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB10679.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB10679.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC superfamily. IRG family. {ECO:0000256|ARBA:ARBA00005429}.
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DR EMBL; JH171113; EHB10679.1; -; Genomic_DNA.
DR AlphaFoldDB; G5BN18; -.
DR STRING; 10181.G5BN18; -.
DR InParanoid; G5BN18; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0098542; P:defense response to other organism; IEA:UniProt.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR030385; G_IRG_dom.
DR InterPro; IPR007743; Immunity-related_GTPase-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR32341:SF16; GTP-BINDING PROTEIN; 1.
DR PANTHER; PTHR32341; INTERFERON-INDUCIBLE GTPASE; 1.
DR Pfam; PF05049; IIGP; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51716; G_IRG; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813}.
FT DOMAIN 27..183
FT /note="IRG-type G"
FT /evidence="ECO:0000259|PROSITE:PS51716"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EHB10679.1"
SQ SEQUENCE 347 AA; 38761 MW; A07B6F2E6B1BCE5E CRC64;
IQAAFKEGNL QAVVDLIQEI LGAAENAVLE LAVIGESGTG KSSFINALRG LGHGEEGAAD
VGVVETTMKK TPYQHPKYPN VTFWDLPGTG TARFAPDTYL ETKIKELGKK FYFVRTKVDS
DLDNEQEAKP QFFKRERVLQ HIQDYCLANL SDIRLPDARV FLVSNFDLCD FDFPLLETTL
LAELPAHKRQ AFALMLPTLS DASVELKRGF LREKIWLDTV KSSALAFIPF VPIIRGFDLP
EQEACLKLYR SYFGLDDESI EEIAEKLGTS VQDIKGYTKC LDFWPLVKDD SIVAKATHCV
ETFCSVNGGL ASVACQFLKN YFLRLKFLDT VADDAKLLLR KIISAQA
//
