ID G5BNF3_HETGA Unreviewed; 512 AA.
AC G5BNF3;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 46.
DE SubName: Full=Chloride intracellular channel protein 5 {ECO:0000313|EMBL:EHB10894.1};
GN ORFNames=GW7_19171 {ECO:0000313|EMBL:EHB10894.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB10894.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB10894.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the chloride channel CLIC family.
CC {ECO:0000256|ARBA:ARBA00007655}.
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DR EMBL; JH171133; EHB10894.1; -; Genomic_DNA.
DR AlphaFoldDB; G5BNF3; -.
DR STRING; 10181.G5BNF3; -.
DR eggNOG; KOG1422; Eukaryota.
DR InParanoid; G5BNF3; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005254; F:chloride channel activity; IEA:UniProtKB-KW.
DR CDD; cd03061; GST_N_CLIC; 1.
DR Gene3D; 1.20.1050.10; -; 2.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR InterPro; IPR002946; CLIC.
DR InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR InterPro; IPR004045; Glutathione_S-Trfase_N.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR PANTHER; PTHR45476:SF4; CHLORIDE INTRACELLULAR CHANNEL PROTEIN 5; 1.
DR PANTHER; PTHR45476; CHLORIDE INTRACELLULAR CHANNEL PROTEIN 6-RELATED; 1.
DR Pfam; PF13410; GST_C_2; 1.
DR Pfam; PF13409; GST_N_2; 1.
DR PRINTS; PR01263; INTCLCHANNEL.
DR SUPFAM; SSF47616; GST C-terminal domain-like; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
PE 3: Inferred from homology;
KW Chloride {ECO:0000256|ARBA:ARBA00023214};
KW Chloride channel {ECO:0000256|ARBA:ARBA00023173};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022882};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT DOMAIN 177..240
FT /note="GST N-terminal"
FT /evidence="ECO:0000259|Pfam:PF13409"
FT REGION 65..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 65..84
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 512 AA; 56517 MW; 4C2E5DFC7A8397EA CRC64;
MTDRAMANGD DRDPEIELFV KMRKGFRGRL LVFPKVIQVT EEELVLMHSC SESVMVQTSW
RKHGAEACSP HDSQEARKGS KEQKGPGSPK PLGELTLWGP ALLPNSATAT QSETEVIQAF
LSMCEVAGEL QAVGAGHLVC TSDEVTVIYH VVPRIPIHVA ASQRSKAGID GESIGNCPFS
QRLFMILWLK GVVFNVTTVD LKRKPADLHN LAPGTHPPFL TFNGEVKTDV NKIEEFLEET
LAPEKYPKLA SKHRESNTAG IDIFSKFSAY IKNTKQQNNA AQGDKGALND PFAHKLNTLP
SGHRDPVQHN RYLVFVQLAL AAVFLKLSSE RTHAQFVCVP MSLWTGKGRH VLLRGAGSHT
NNLEEERLAC KVLSGLVPTC GPDSFTVGTM VSGPPALERG LTKALRKLDD YLSTPLPEEI
DINTLGDNDK GSRRKFLDGD ELTLADCNLL PKLHVVKIVA KKYRNYDFPA EMTGLWRYLK
NAYARDEFTN TCAADSEIEL AYADVAKRLS RS
//