ID G5BPE8_HETGA Unreviewed; 346 AA.
AC G5BPE8;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE SubName: Full=HMG domain-containing protein 4 {ECO:0000313|EMBL:EHB11159.1};
GN ORFNames=GW7_07168 {ECO:0000313|EMBL:EHB11159.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB11159.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB11159.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
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DR EMBL; JH171263; EHB11159.1; -; Genomic_DNA.
DR AlphaFoldDB; G5BPE8; -.
DR STRING; 10181.G5BPE8; -.
DR eggNOG; ENOG502QSH9; Eukaryota.
DR InParanoid; G5BPE8; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd21982; HMG-box_HMGXB4; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR InterPro; IPR025228; DUF4171.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR042477; HMGXB4.
DR InterPro; IPR048016; HMGXB4_HMG-box.
DR PANTHER; PTHR46584; HMG DOMAIN-CONTAINING PROTEIN 4; 1.
DR PANTHER; PTHR46584:SF1; HMG DOMAIN-CONTAINING PROTEIN 4; 1.
DR Pfam; PF13775; DUF4171; 1.
DR Pfam; PF00505; HMG_box; 1.
DR PRINTS; PR00886; HIGHMOBLTY12.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; HMG-box; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00267}; Reference proteome {ECO:0000313|Proteomes:UP000006813}.
FT DOMAIN 152..220
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 152..220
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 77..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 240..261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 77..112
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 243..258
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 346 AA; 37739 MW; 8780A73B1B785019 CRC64;
MRQPDLAESS KLPASRDCFD GDHGFEDLGL AAGRSQREKR RSYKDFLREE EEIAAQVRNS
SKKKLKLQDT ELCFLGTDVH RKKRKRSPDD SHYGDISSLE SAQKKKKRSS SQAADTAMDL
LKAITSPLAA GAHPPRKAGE KSSGSSGHGQ PKKKNVSAYQ VFCKEYRATI VADHPGIDFG
ELSKKLAEVW KQLPEKDKLI WKQKAQYLQH KQNKAEATTV KRKVSASEGS VKVKAPSTGV
LLPQKKSPPT TVLLPTSPSR APETEPIDVA AHLQLLGESL SLIGHRLQET EGMVAVSGSL
SVLLDSIICA LGPLACLTTQ LPELNGCPKQ VLSNTLDNVA YIMPGL
//
