ID G5BQK6_HETGA Unreviewed; 489 AA.
AC G5BQK6;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Inositol-pentakisphosphate 2-kinase {ECO:0000256|ARBA:ARBA00014846, ECO:0000256|RuleBase:RU364126};
DE EC=2.7.1.158 {ECO:0000256|ARBA:ARBA00012023, ECO:0000256|RuleBase:RU364126};
GN Name=IPPK {ECO:0000313|EMBL:JAN98665.1};
GN ORFNames=GW7_11599 {ECO:0000313|EMBL:EHB11566.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB11566.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB11566.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
RN [2] {ECO:0000313|EMBL:JAN98665.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Skin {ECO:0000313|EMBL:JAN98665.1};
RA Bens M., Sahm A., Jahn N., Morhart M., Holtze S., Hildebrandt T.B.,
RA Platzer M., Szafranski K.;
RT "FRAMA: From RNA-seq data to annotated mRNA assemblies.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form
CC Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). {ECO:0000256|RuleBase:RU364126}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-
CC inositol hexakisphosphate + ADP + H(+); Xref=Rhea:RHEA:20313,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57733,
CC ChEBI:CHEBI:58130, ChEBI:CHEBI:456216; EC=2.7.1.158;
CC Evidence={ECO:0000256|RuleBase:RU364126};
CC -!- DOMAIN: The EXKPK motif is conserved in inositol-pentakisphosphate 2-
CC kinases of both family 1 and 2. {ECO:0000256|RuleBase:RU364126}.
CC -!- SIMILARITY: Belongs to the IPK1 type 2 family.
CC {ECO:0000256|ARBA:ARBA00007229}.
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DR EMBL; JH171411; EHB11566.1; -; Genomic_DNA.
DR EMBL; GEBF01004967; JAN98665.1; -; Transcribed_RNA.
DR RefSeq; XP_004870138.1; XM_004870081.2.
DR AlphaFoldDB; G5BQK6; -.
DR STRING; 10181.G5BQK6; -.
DR Ensembl; ENSHGLT00100006082; ENSHGLP00100005999; ENSHGLG00100004520.
DR GeneID; 101698360; -.
DR KEGG; hgl:101698360; -.
DR CTD; 64768; -.
DR eggNOG; KOG4749; Eukaryota.
DR InParanoid; G5BQK6; -.
DR OMA; NCVHCGE; -.
DR OrthoDB; 8233at2759; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR Bgee; ENSHGLG00000007938; Expressed in hypothalamus and 10 other cell types or tissues.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0035299; F:inositol pentakisphosphate 2-kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 3.30.200.110; Inositol-pentakisphosphate 2-kinase, N-lobe; 1.
DR InterPro; IPR009286; Ins_P5_2-kin.
DR InterPro; IPR043001; IP5_2-K_N_lobe.
DR PANTHER; PTHR14456; INOSITOL POLYPHOSPHATE KINASE 1; 1.
DR PANTHER; PTHR14456:SF2; INOSITOL-PENTAKISPHOSPHATE 2-KINASE; 1.
DR Pfam; PF06090; Ins_P5_2-kin; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU364126};
KW Kinase {ECO:0000256|RuleBase:RU364126, ECO:0000313|EMBL:EHB11566.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU364126};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU364126}.
SQ SEQUENCE 489 AA; 55870 MW; 5E945D840CF9A06A CRC64;
MEEEKMDENE WGYHGEGNKS LVVAHAQRCV VLRFLKFPPN RKKTSEEIFQ HLQDIVDFGK
NVMKEFLGEN CVHCGEVVQL PLEFVKQLCL KIQSERPESR CDKELDTLSG YAMCLPNLTR
LQTYRIAEHR PILCVEIKPK CGFIPFSSSV THEMKHKVCR YCMHQHLKVA TGKWKQISKY
CPLDLFSGNK QRMHFALKSL LQESQNNLKI FKNGELIYGC GDARSPVADW RELAYHLKPF
FFPSNGLAGG AHCTRAVIRE LVHVITRVLL SSSDKGQVGA LRPGPWGLHV CEASPFSRSL
HHQGKNTPER SGLPKGCLLY KTLQVQMLDL LDIEGLYPLY NRVERYLEEF PKERKMLQID
GPYDEAFHQK LLDLSTEDDG TVAFALTKVQ QYRVAMTAKD CSIMIALSPC LQDASSDQRL
VVPSSRSRLA FSVSVLDLDL KPYESIPHQY KLDAKIVNYY SKTVHAKDDT VMSTRFKESE
DCTLVLHKV
//
