ID G5BR76_HETGA Unreviewed; 1030 AA.
AC G5BR76;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Solute carrier family 12 member 3 {ECO:0000313|EMBL:EHB11787.1};
GN ORFNames=GW7_14912 {ECO:0000313|EMBL:EHB11787.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB11787.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB11787.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JH171519; EHB11787.1; -; Genomic_DNA.
DR RefSeq; XP_004843251.1; XM_004843194.2.
DR AlphaFoldDB; G5BR76; -.
DR STRING; 10181.G5BR76; -.
DR GeneID; 101704301; -.
DR KEGG; hgl:101704301; -.
DR CTD; 6559; -.
DR eggNOG; KOG2083; Eukaryota.
DR InParanoid; G5BR76; -.
DR OrthoDB; 5490251at2759; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0016324; C:apical plasma membrane; IEA:UniProt.
DR GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR GO; GO:0046873; F:metal ion transmembrane transporter activity; IEA:UniProt.
DR GO; GO:0035725; P:sodium ion transmembrane transport; IEA:UniProt.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR013612; AA_permease_N.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR002948; SLC12A3.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF9; SOLUTE CARRIER FAMILY 12 MEMBER 3; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 1.
DR Pfam; PF08403; AA_permease_N; 1.
DR Pfam; PF03522; SLC12; 2.
DR PRINTS; PR01230; NACLTRNSPORT.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|ARBA:ARBA00023201};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023201}.
FT TRANSMEM 142..162
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 168..194
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 215..239
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 259..278
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 287..306
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 340..362
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 374..393
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 452..474
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 506..525
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 531..552
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 586..605
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 46..116
FT /note="Amino acid permease N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08403"
FT DOMAIN 141..646
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 655..789
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 826..1029
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
SQ SEQUENCE 1030 AA; 113764 MW; F9AEA24B94724820 CRC64;
MAELPTAEMP RDPALCSGRF TISTLLGGDE SLPTAAYDTS HPNHLTHGST LYMRTFGYNT
IDVVPAYEHY ADSALPGEPR KIRPTLADLH SFLKQEGSHL HALAFDSQPS HELTDGLVED
EAGTHGETSP GEPVRFGWVK GVMIRCMLNI WGVILYLRLP WITAQAGIVL TWIIILLSVT
VTSITGLSIS AISTNGKVKS GGTYFLISRS LGPELGGSIG LIFAFANAVG VSMHTVGFAE
TVRDLLQEYG VPIVDPINDI RIIGVVTVTV LLGISLAGME WESKAQVLFF LVIMVSFANY
LVGTLIPPSE DKASKGFFSY RGDIFVQNLV PDWRGIDGSF FGMFSIFFPS ATGILAGANI
SGDLKDPAVA IPRGTLMAIF WTTISYLAVS ATIGSCVVRD ASGDLNDTVT SGLGTCEGLA
CNYGWNFTKC SQQHSCRYGL INYYQTMSMV SAFAPLITAG IFGATLSSAL ACLVSAAKVF
QCLCEDQLYP LIGFFGKGYG KNKEPVRGYL LAYAIAVAFI IIAELNTIAP IISNFFLCSY
ALINFSCFHA SITNSPGWRP SFQYYSKWAA LFGAVISVVI MFLLTWWAAL IAIGVVLFLL
LYVIYKKPEV NWGSSVQAGS YNLALSYSMG LIEVEDHIKN YRPQCLVLTG PPNFRPALVD
FVGTFTQNLS LMICGHVLIG PHKQRMPELR LLANGHTKWL KKRKVKAFYS DVIAEDLRSG
VQILMQAVGL GRMKPNILVV GFKKNWQSAH PATVEDYISI LHDAFDFNYG MCIMRMREGL
NVSEVMQAHI NPVFDPAEDS KGASTGGARQ SVSGTLDPEA LVWEEQASTI FQSEQAKKTI
DIYWLFDDGG LTLLIPYLLH RKKRWAKCKI RVFVGGQINR LDQERKAIIS LLSKFRLGFH
EVHILPDINQ KPNAEHIKRF EDMIAPFRLN DGFKDEATVA EMRRDCPWKI SDEEVNKNRV
KSLRQVRLNE ILLDYSQDAA LVVITLPIGR KGKCPSSLYM AWLETLSQDL RPPVILIRGN
QENVLTFYCQ
//
