ID G5BRG5_HETGA Unreviewed; 694 AA.
AC G5BRG5;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 44.
DE SubName: Full=Semaphorin-7A {ECO:0000313|EMBL:EHB11876.1};
GN ORFNames=GW7_19539 {ECO:0000313|EMBL:EHB11876.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB11876.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB11876.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SIMILARITY: Belongs to the semaphorin family.
CC {ECO:0000256|ARBA:ARBA00009492}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR EMBL; JH171542; EHB11876.1; -; Genomic_DNA.
DR AlphaFoldDB; G5BRG5; -.
DR STRING; 10181.G5BRG5; -.
DR eggNOG; KOG3611; Eukaryota.
DR InParanoid; G5BRG5; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0030215; F:semaphorin receptor binding; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR CDD; cd11243; Sema_7A; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR042824; Sema7A_sema.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR027231; Semaphorin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR11036; SEMAPHORIN; 1.
DR PANTHER; PTHR11036:SF80; SEMAPHORIN-7A; 1.
DR Pfam; PF13895; Ig_2; 1.
DR Pfam; PF01437; PSI; 1.
DR Pfam; PF01403; Sema; 1.
DR SMART; SM00423; PSI; 1.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813}.
FT DOMAIN 78..518
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT DOMAIN 572..647
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 694 AA; 78456 MW; 4974DC6AF161EA8B CRC64;
MRKPKLALAQ KVRGVQTGHS GFGDSDGREI GPDSVQLDQN PTSSLVEGLY LHRTASHSPA
MLLIPSIWLE LGWAVWAQPL CRHGDPGHTG QDRLDFGRAE PHTVLFHEPG SPSVWVGGRG
KVYRFDFPEG KNASVHMVNI SSTKGTCVDK QQDCENYITL LERRSEGLLA CGTNARRPSC
WNLVNDTVVP LGEMRGYAPF SPDENSLVLF EGDEVYSTIR KQEYNGKIPR FRRIQGESEL
YTSDTVMQNP QFIKATIVHQ DQAYDDKIYY FFREDNPDKN PESPLNVSRV AQLCRGDQGG
ESSLSVSKWN TFLKAMLVCS DATTNKNFNR LQDVFLLPDP SGNWKDTKVY GVFSNPWNYS
AVCVYSLGDI DRVFRTSSLK GYHMGLPNPR PGKCLPNQKP IPTQTFQVAD SHPEVAQRVE
PMGPLKMPLF HSKYHYQKVV VHRMQARNEG TFHVLYLTTD RGTIHKVVES GEREHSVAFN
IMEIQPFHRM AAIQGISLDA ERRKLYVTSQ WEVSQVPLDL CDVYGGGCHG CLMSRDPYCG
WDQDRCVSIY SCQRPLLQSI NPAEPHKECP NPKPDEAPLQ KVSLARNSRY YLSCPMESRH
ATYSWRHEEN VEQSCEPGHQ SPNCILFIEN LTARQYGHYR CEAREGSYLR EAQHWELLPE
DRALAEHLLG HACVLATSLW LGVLPTLALG LLVH
//