GenomeNet

Database: UniProt
Entry: G5BRN6_HETGA
LinkDB: G5BRN6_HETGA
Original site: G5BRN6_HETGA 
ID   G5BRN6_HETGA            Unreviewed;       374 AA.
AC   G5BRN6;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   31-JUL-2019, entry version 31.
DE   SubName: Full=Friend leukemia integration 1 transcription factor {ECO:0000313|EMBL:EHB11947.1};
GN   ORFNames=GW7_05539 {ECO:0000313|EMBL:EHB11947.1};
OS   Heterocephalus glaber (Naked mole rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricomorpha; Bathyergidae; Heterocephalus.
OX   NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB11947.1, ECO:0000313|Proteomes:UP000006813};
RN   [1] {ECO:0000313|EMBL:EHB11947.1, ECO:0000313|Proteomes:UP000006813}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993625; DOI=10.1038/nature10533;
RA   Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA   Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA   Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA   Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L.,
RA   Bronson R.T., Buffenstein R., Wang B., Han C., Li Q., Chen L.,
RA   Zhao W., Sunyaev S.R., Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT   "Genome sequencing reveals insights into physiology and longevity of
RT   the naked mole rat.";
RL   Nature 479:223-227(2011).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU004019,
CC       ECO:0000256|SAAS:SAAS00594387}.
CC   -!- SIMILARITY: Belongs to the ETS family.
CC       {ECO:0000256|RuleBase:RU004019, ECO:0000256|SAAS:SAAS00594391}.
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DR   EMBL; JH171550; EHB11947.1; -; Genomic_DNA.
DR   STRING; 10181.XP_004862665.1; -.
DR   InParanoid; G5BRN6; -.
DR   Proteomes; UP000006813; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   CDD; cd08541; SAM_PNT-FLI-1; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.150.50; -; 1.
DR   InterPro; IPR000418; Ets_dom.
DR   InterPro; IPR035575; Fli-1.
DR   InterPro; IPR003118; Pointed_dom.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR035573; SAM_PNT-FLI-1.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11849:SF161; PTHR11849:SF161; 2.
DR   Pfam; PF00178; Ets; 1.
DR   Pfam; PF02198; SAM_PNT; 1.
DR   PRINTS; PR00454; ETSDOMAIN.
DR   SMART; SM00413; ETS; 1.
DR   SMART; SM00251; SAM_PNT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR   PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR   PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR   PROSITE; PS51433; PNT; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000006813};
KW   DNA-binding {ECO:0000256|RuleBase:RU004019,
KW   ECO:0000256|SAAS:SAAS00594397};
KW   Nucleus {ECO:0000256|RuleBase:RU004019,
KW   ECO:0000256|SAAS:SAAS00594400};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006813}.
FT   DOMAIN       56    142       PNT. {ECO:0000259|PROSITE:PS51433}.
FT   DOMAIN      203    283       ETS. {ECO:0000259|PROSITE:PS50061}.
FT   REGION        1     31       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION       43     62       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      153    187       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      355    374       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    169    187       Polar. {ECO:0000256|SAM:MobiDB-lite}.
SQ   SEQUENCE   374 AA;  41967 MW;  E8B0F8B794A2802E CRC64;
     MAMPSDGGTK NGGKSGGPAE RESPVDCSVS KCSKLVGGGE SNPINYNSYM DEKNGPPPPN
     MTTNERRVIV PADPTLWTQE HVRQWLEWAI KEYGLMEIDT SFFQNMDGKE LCKMNKEDFL
     HATSLYNTEV LLSHLSYLRE SSLLAYNTTS HTDQSSRLSV KEGPPLGGAQ TMSKSTEQRP
     QPDPYQILGP TSSRLANPGS GQIQLWQFLL ELLSDSANAS CITWEGTNGE FKMTDPDEVA
     RRWGERKSKP NMNYDKLSRA LRYYYDKNIM TKVHGKRYAY KFDFHGIAQA LQPHPTESSM
     YKYPSDISYM PSYHAHQQKV NFVPPHPSSM PVTSSSFFGA ASQYWTSPTG GIYPNPNVPR
     HPNTHVPSHL GSYY
//
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