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Database: UniProt
Entry: G5BUB1_HETGA
LinkDB: G5BUB1_HETGA
Original site: G5BUB1_HETGA 
ID   G5BUB1_HETGA            Unreviewed;       839 AA.
AC   G5BUB1;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   28-FEB-2018, entry version 31.
DE   SubName: Full=Short transient receptor potential channel 6 {ECO:0000313|EMBL:EHB12873.1};
GN   ORFNames=GW7_15543 {ECO:0000313|EMBL:EHB12873.1};
OS   Heterocephalus glaber (Naked mole rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricomorpha; Bathyergidae; Heterocephalus.
OX   NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB12873.1, ECO:0000313|Proteomes:UP000006813};
RN   [1] {ECO:0000313|EMBL:EHB12873.1, ECO:0000313|Proteomes:UP000006813}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993625; DOI=10.1038/nature10533;
RA   Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA   Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA   Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA   Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L.,
RA   Bronson R.T., Buffenstein R., Wang B., Han C., Li Q., Chen L.,
RA   Zhao W., Sunyaev S.R., Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT   "Genome sequencing reveals insights into physiology and longevity of
RT   the naked mole rat.";
RL   Nature 479:223-227(2011).
CC   -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family.
CC       {ECO:0000256|SAAS:SAAS01006510}.
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DR   EMBL; JH171904; EHB12873.1; -; Genomic_DNA.
DR   InParanoid; G5BUB1; -.
DR   Proteomes; UP000006813; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005262; F:calcium channel activity; IEA:InterPro.
DR   CDD; cd00204; ANK; 1.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR004729; TRP_channel.
DR   InterPro; IPR013555; TRP_dom.
DR   InterPro; IPR005462; TRPC6_channel.
DR   InterPro; IPR002153; TRPC_channel.
DR   PANTHER; PTHR10117; PTHR10117; 2.
DR   PANTHER; PTHR10117:SF7; PTHR10117:SF7; 2.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08344; TRP_2; 1.
DR   PRINTS; PR01097; TRNSRECEPTRP.
DR   PRINTS; PR01647; TRPCHANNEL6.
DR   SMART; SM00248; ANK; 3.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   TIGRFAMs; TIGR00870; trp; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 2.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
PE   3: Inferred from homology;
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023,
KW   ECO:0000256|SAAS:SAAS00933366}; Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006813};
KW   Ion channel {ECO:0000256|SAAS:SAAS00790162};
KW   Ion transport {ECO:0000256|SAAS:SAAS00790154};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:EHB12873.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW   Repeat {ECO:0000256|SAAS:SAAS00931009};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|SAAS:SAAS00788392}.
FT   TRANSMEM    365    384       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    404    423       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    451    469       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    489    508       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    595    617       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    664    685       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       66    116       ANK_REP_REGION. {ECO:0000259|PROSITE:
FT                                PS50297}.
FT   REPEAT      179    211       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
FT   DOMAIN      179    211       ANK_REP_REGION. {ECO:0000259|PROSITE:
FT                                PS50297}.
FT   COILED      792    827       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   839 AA;  96137 MW;  C537E10D834DE12E CRC64;
     MVYQVFGCHL SLYSGSICRG TDNRLTHRRQ TVLREKGRRL ANRGPAYMFN DHSTSLSIEE
     ERFLDAAEYG NIPVVRKMLE ECLSLNVNCV DYMGQNALQL AVANEHLEIT ELLLKKENLS
     RVGDALLLAI SKGYVRIVEA ILSHPAFAEG KRLATSPSQS ELQQDDFYAY DEDGTRFSHD
     VTPIILAAHC QEYEIVHTLL RKGARIERPH DYFCKCNECN QKQKHDSFSH SRSRINAYKG
     LASPAYLSLS SEDPVMTALE LSNELAVLAN IEKEFKNDYK KLSMQCKDFV VGLLDLCRNT
     EEVEAILNGD VETCQPGDQG RPNLSRLKLA IKYEVKKFVA HPNCQQQLLS IWYENLSGLR
     QQTMAVKFLV VLGVAIGLPF LALIYWCAPC SKMGKIMRGP FMKFVAHAAS FTIFLGLLVM
     NAADRFEGTK LLPNETSTDN AKQLFRMKTS CFSWMEMLII SWVIGMIWAE CKEIWTQGPK
     EYLFELWNML DFGMLAIFAA SFIARFMAFW HASKAQSIID ANDTLKDLTK VTLGDNVKYY
     NLARIKWDPS DPQIISEGLY AIAVVLSFSR IAYILPANES FGPLQISLGR TVKDIFKFMV
     IFIMVFVAFM IGMFNLYSYY IGAKQNEAFT TVEESFKTLF WAIFGLSEVK SVVINYNHKF
     IENIGYVLYG VYNVTMVIVL LNMLIAMINS SFQEIEDDAD VEWKFARAKL WFSYFEEGRT
     LPVPFNLMPS PKSLLYLLLK FKKWISELFQ GHKKGFQEDA EMNKKIMKRL IKRYVLQAQI
     DKESDEVNEG ELKEIKQDIS SLRYELLEEK SQNTEDLAEL IRKLGEKLSS EPKQEENNR
//
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