ID G5BVP5_HETGA Unreviewed; 1384 AA.
AC G5BVP5;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 43.
DE RecName: Full=protein-serine/threonine phosphatase {ECO:0000256|ARBA:ARBA00013081};
DE EC=3.1.3.16 {ECO:0000256|ARBA:ARBA00013081};
GN ORFNames=GW7_08206 {ECO:0000313|EMBL:EHB13340.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB13340.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB13340.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-
CC COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:61977; EC=3.1.3.16;
CC Evidence={ECO:0000256|ARBA:ARBA00001482};
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC {ECO:0000256|ARBA:ARBA00009580}.
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DR EMBL; JH172092; EHB13340.1; -; Genomic_DNA.
DR STRING; 10181.G5BVP5; -.
DR eggNOG; KOG1716; Eukaryota.
DR InParanoid; G5BVP5; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0017018; F:myosin phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IEA:InterPro.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR GO; GO:0030837; P:negative regulation of actin filament polymerization; IEA:InterPro.
DR CDD; cd14569; DSP_slingshot_2; 1.
DR CDD; cd11652; SSH-N; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR014876; DEK_C.
DR InterPro; IPR000340; Dual-sp_phosphatase_cat-dom.
DR InterPro; IPR043587; Phosphatase_SSH-like.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR043588; SSH-N.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR InterPro; IPR020422; TYR_PHOSPHATASE_DUAL_dom.
DR PANTHER; PTHR45864:SF3; PROTEIN PHOSPHATASE SLINGSHOT HOMOLOG 2; 1.
DR PANTHER; PTHR45864; SLINGSHOT PROTEIN PHOSPHATASE HOMOLOG; 1.
DR Pfam; PF08766; DEK_C; 1.
DR Pfam; PF00782; DSPc; 1.
DR SMART; SM00195; DSPc; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR PROSITE; PS51998; DEK_C; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50054; TYR_PHOSPHATASE_DUAL; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813}.
FT DOMAIN 222..277
FT /note="DEK-C"
FT /evidence="ECO:0000259|PROSITE:PS51998"
FT DOMAIN 281..422
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50054"
FT DOMAIN 346..400
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 586..607
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 633..694
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 801..829
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 844..914
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 984..1005
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1041..1069
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1104..1141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1341..1384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 633..649
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 664..683
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 852..872
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 879..902
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1046..1069
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1104..1126
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1384 AA; 155254 MW; ED721D84FA66A5A8 CRC64;
MPECRSQPRS ISESFLTVKG AALFLPRGNG SSTPRISHRR NKHAGDLQQH LQAMFILLRP
EDNIRLAVRL ESTYQNRTRY MVVVSTNGRQ DTEESIVLGM DFSSNDSSTC TMGLVLPLWS
DTLIHLDGDG GFSVSTDNRV HIFKPVSVQA MWSALQSLHK ACEVARMHNY YPGSLFLTWV
SYYESHINSD QSSVNEWNAM QDVQSHRPDS PALFTDIPTE RERTERLIKT KLREIMMQKD
LENITSKEIR TELEMQMVCN LREFKEFIDN EMIVILGQMD SPTQIFEHVF LGSEWNASNL
EDLQNRGVRY ILNVTREIDN FFPGVFEYHN IRVYDEEATD LLAYWNDTYK FISKAKKHGS
KCLVHCKMGV SRSASTVIAY AMKEYGWNLD RAYDYVKERR TVTKPNPSFM RQLEEYQGIL
LASKQRHNKL WRSHSDSDLS DHHEPICKPG LELNKKEITT SADQIAEVKT LESHPSIPPV
FVEHVVPQDT KERMICLEFT SREFHAGQIE DELNLNDING CSSGFCLNES KFPLDNCHAS
KALIQPGQVP EMANKFPDLT VEDLETDALK ADINVHLLPM EELTSGLKDL PMSPDPESPS
PQPSCQAEIS DFSTDRIDFF SALEKFVELS QETRSRSFSH SRMEELGGGR SESCRLSVVE
VPPSEATTDD QRSSSLSNTP HASEESSMDE EQSKAISELI SPDIFIHSHS ENSISVKEIV
TEIESISQGV GQMQLKGDMV SNPCHTPKKS TIHELSLERT QAPENKPGHM EQDEGFCPAQ
PELAKDSGKC NPEDCLTTHS STVDLEEEEP TEGEHELWGP GMHSGAKWCP GSVRRATLEF
EERLRQEQDH HSPAPVCTSM STRKNSKNDS SVADLAPKGK NDEATEYSFA PKEPEVSKGK
GKCSKSEAGS LSQCEQNATV PALELLEYHP LAATQEYPRL DIRTKQGVPE EQGTVVPCQG
SETQDILLPK RIEIIEYTHT VTSLSHTGSG GERATSKEKG DQGLRKVKVE KSVTMLCALD
ENLNRTLDPS QLSLHPQMLP LLHSSPEQDR PTNPTSMLSS PEDRDNSPLT ALETTAPFIS
HTTHILPANF DYLHPQTIVH LEGCTEQSST TDSEPSAEQV SWEESQKGHL SGGDEAPHKG
SQLNCKDLNL ISKLDDNIGE LQKKLDPSQV AWRLPHSSSS ENIKGLSHSP GVVKERAKEI
ESRVIFQVRI PKPSQMRRSA SLAKLGYLDL CKDCLPERES VSSESPHLKV LQPFIRTDSG
MHAMEAQAPP ENLDATQNTE PTKYFVEPLK TTECIAQSKP VERPLVQYAK EFGYSQQCLL
PRVRRELTSS EGGLPLLQTQ GLQDAGPAPG LAMAPRQQHG RTHPLRRLRT NDKKRTTNPF
YNTM
//
