ID G5BVT4_HETGA Unreviewed; 389 AA.
AC G5BVT4;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Elongation factor 1-alpha 1 {ECO:0000313|EMBL:EHB13399.1};
GN ORFNames=GW7_16664 {ECO:0000313|EMBL:EHB13399.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB13399.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB13399.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A
CC subfamily. {ECO:0000256|ARBA:ARBA00007249}.
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DR EMBL; JH172097; EHB13399.1; -; Genomic_DNA.
DR AlphaFoldDB; G5BVT4; -.
DR STRING; 10181.G5BVT4; -.
DR InParanoid; G5BVT4; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR CDD; cd03693; EF1_alpha_II; 1.
DR CDD; cd03705; EF1_alpha_III; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004160; Transl_elong_EFTu/EF1A_C.
DR PANTHER; PTHR23115:SF222; ELONGATION FACTOR 1-ALPHA 1-RELATED; 1.
DR PANTHER; PTHR23115; TRANSLATION FACTOR; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF03143; GTP_EFTU_D3; 1.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
PE 3: Inferred from homology;
KW Elongation factor {ECO:0000313|EMBL:EHB13399.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000313|EMBL:EHB13399.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813}.
FT DOMAIN 63..165
FT /note="Tr-type G"
FT /evidence="ECO:0000259|Pfam:PF00009"
FT DOMAIN 188..252
FT /note="Translation elongation factor EFTu-like"
FT /evidence="ECO:0000259|Pfam:PF03144"
FT DOMAIN 263..368
FT /note="Translation elongation factor EFTu/EF1A C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03143"
SQ SEQUENCE 389 AA; 42295 MW; 8B2A470DB9DFECCE CRC64;
MGKEKTHINI IIIEHVDLGK PTTTSHLIYK CGINKRTIEK FEEAADMGKG SFKYAWVLDK
LKAECEHGTS QADCAVLIVA AGVGEFEAGI SKNGQTHEHA LLAYMLSVKQ LIVGVNKIDS
TEPPYSQKRY EEIVKEVITY IKKIGYNPDT VAFVQISGWN GDNMLEPSAD MPWFKGWKDV
YKIGGISTIP VGRVETVVPK PGMVVTFTSV YVTTEVKSVE MHHEALSEAL PGVNVGFNIK
NVSVKDVHSG NVAGDSKTDP PMEAAGFIAQ VIILNHPGQI SAGYAPVLDC HTAHIACKFA
ELKEKIDCRS GKKLEDDPKF LKSGDAAIID MVPGKSMCVE SFSDYPPLCC FSVFNMRQTV
AVGVIKAVDK KAAGAGKVTK FSQKAQKAK
//
